IL13RA1 (interleukin 13 receptor subunit alpha 1)

2013-08-01  

Identity

HGNC
IL13RA1
LOCATION
Xq24
LOCUSID
3597
ALIAS
CD213A1,CT19,IL-13Ra,NR4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3597
MIM: 300119
HGNC: 5974
Ensembl: ENSG00000131724

Variants:

dbSNP: 3597
ClinVar: 3597
TCGA: ENSG00000131724
COSMIC: IL13RA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131724ENST00000371642P78552
ENSG00000131724ENST00000371666P78552
ENSG00000131724ENST00000652600A0A494C1C4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

References

Pubmed IDYearTitleCitations
354090192022Loss of Interleukin-13-Receptor-Alpha-1 Induces Apoptosis and Promotes EMT in Pancreatic Cancer.4
354090192022Loss of Interleukin-13-Receptor-Alpha-1 Induces Apoptosis and Promotes EMT in Pancreatic Cancer.4
336382962021Identification of serum interleukin-13 and interleukin-13 receptor subunit expressions: Rheumatoid arthritis-associated interstitial lung disease.8
336382962021Identification of serum interleukin-13 and interleukin-13 receptor subunit expressions: Rheumatoid arthritis-associated interstitial lung disease.8
301079112018IL-13 and IL-13Rα1 are overexpressed in extranodal natural killer/T cell lymphoma and mediate tumor cell proliferation.5
301079112018IL-13 and IL-13Rα1 are overexpressed in extranodal natural killer/T cell lymphoma and mediate tumor cell proliferation.5
285283242017New Role for Interleukin-13 Receptor α1 in Myocardial Homeostasis and Heart Failure.19
286346672017Elevated Interleukin-13 Receptor Alpha 1 Expression in Tumor Cells Is Associated with Poor Prognosis in Patients with Invasive Breast Cancer.15
288743582017Soluble interleukin-13rα1: a circulating regulator of glucose.2
285283242017New Role for Interleukin-13 Receptor α1 in Myocardial Homeostasis and Heart Failure.19
286346672017Elevated Interleukin-13 Receptor Alpha 1 Expression in Tumor Cells Is Associated with Poor Prognosis in Patients with Invasive Breast Cancer.15
288743582017Soluble interleukin-13rα1: a circulating regulator of glucose.2
261537642016A protective role for IL-13 receptor α 1 in bleomycin-induced pulmonary injury and repair.25
270485052016MicroRNA-143 inhibits IL-13-induced dysregulation of the epidermal barrier-related proteins in skin keratinocytes via targeting to IL-13Rα1.18
275334632016IL-13/STAT6 signaling plays a critical role in the epithelial-mesenchymal transition of colorectal cancer cells.51

Citation

Dessen P

IL13RA1 (interleukin 13 receptor subunit alpha 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-08-01

Online version: http://atlasgeneticsoncology.org/gene/53486/gene-explorer/favicon/case-report-explorer/