ME1 (malic enzyme 1)

2013-09-01  

Identity

HGNC
ME1
LOCATION
6q14.2
LOCUSID
4199
ALIAS
HUMNDME,MES
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4199
MIM: 154250
HGNC: 6983
Ensembl: ENSG00000065833

Variants:

dbSNP: 4199
ClinVar: 4199
TCGA: ENSG00000065833
COSMIC: ME1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000065833ENST00000369705P48163

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pyruvate metabolismKEGGko00620
PPAR signaling pathwayKEGGko03320
Pyruvate metabolismKEGGhsa00620
PPAR signaling pathwayKEGGhsa03320
Metabolic pathwaysKEGGhsa01100
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
374103612023Cytosolic malic enzyme and glucose-6-phosphate dehydrogenase modulate redox balance in NSCLC with acquired drug resistance.1
374103612023Cytosolic malic enzyme and glucose-6-phosphate dehydrogenase modulate redox balance in NSCLC with acquired drug resistance.1
357276982022Targeting Ferroptosis Vulnerability in Synovial Sarcoma: Is It All About ME1?1
357276982022Targeting Ferroptosis Vulnerability in Synovial Sarcoma: Is It All About ME1?1
336197712021Adaptive and Constitutive Activations of Malic Enzymes Confer Liver Cancer Multilayered Protection Against Reactive Oxygen Species.11
337518972021miR-885-5p Inhibits Invasion and Metastasis in Gastric Cancer by Targeting Malic Enzyme 1.7
336197712021Adaptive and Constitutive Activations of Malic Enzymes Confer Liver Cancer Multilayered Protection Against Reactive Oxygen Species.11
337518972021miR-885-5p Inhibits Invasion and Metastasis in Gastric Cancer by Targeting Malic Enzyme 1.7
317356432020Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis.48
329982652020Malic Enzyme 1 Is Associated with Tumor Budding in Oral Squamous Cell Carcinomas.10
317356432020Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis.48
329982652020Malic Enzyme 1 Is Associated with Tumor Budding in Oral Squamous Cell Carcinomas.10
296011262018Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma.26
296201922018Tumor-suppressing effects of microRNA-612 in bladder cancer cells by targeting malic enzyme 1 expression.23
296541552018ME1 Regulates NADPH Homeostasis to Promote Gastric Cancer Growth and Metastasis.56

Citation

Dessen P

ME1 (malic enzyme 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-09-01

Online version: http://atlasgeneticsoncology.org/gene/53518/gene-explorer/css/favicon/meetings/