PTBP2 (polypyrimidine tract binding protein 2)

2013-11-01  

Identity

HGNC
PTBP2
LOCATION
1p21.3
LOCUSID
58155
ALIAS
PTBLP,brPTB,nPTB
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 58155
MIM: 608449
HGNC: 17662
Ensembl: ENSG00000117569

Variants:

dbSNP: 58155
ClinVar: 58155
TCGA: ENSG00000117569
COSMIC: PTBP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117569ENST00000370197Q9UKA9
ENSG00000117569ENST00000370198Q9UKA9
ENSG00000117569ENST00000426398Q9UKA9
ENSG00000117569ENST00000609116Q9UKA9

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385973902024KIS counteracts PTBP2 and regulates alternative exon usage in neurons.1
385973902024KIS counteracts PTBP2 and regulates alternative exon usage in neurons.1
371497172023Mapping PTBP2 binding in human brain identifies SYNGAP1 as a target for therapeutic splice switching.7
371497172023Mapping PTBP2 binding in human brain identifies SYNGAP1 as a target for therapeutic splice switching.7
352959602022Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants.0
352959602022Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants.0
344591242021LncRNA nuclear-enriched abundant transcript 1 shuttled by prostate cancer cells-secreted exosomes initiates osteoblastic phenotypes in the bone metastatic microenvironment via miR-205-5p/runt-related transcription factor 2/splicing factor proline- and glutamine-rich/polypyrimidine tract-binding protein 2 axis.27
345484892021SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity.21
344591242021LncRNA nuclear-enriched abundant transcript 1 shuttled by prostate cancer cells-secreted exosomes initiates osteoblastic phenotypes in the bone metastatic microenvironment via miR-205-5p/runt-related transcription factor 2/splicing factor proline- and glutamine-rich/polypyrimidine tract-binding protein 2 axis.27
345484892021SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity.21
307267132019PTBP2 exon 10 inclusion is associated with the progression of CML and it is BCR-ABL1 dependent.1
307267132019PTBP2 exon 10 inclusion is associated with the progression of CML and it is BCR-ABL1 dependent.1
266576382016Human polypyrimidine tract-binding protein interacts with mitochondrial tRNA(Thr) in the cytosol.9
276814242016PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons.39
266576382016Human polypyrimidine tract-binding protein interacts with mitochondrial tRNA(Thr) in the cytosol.9

Citation

Dessen P

PTBP2 (polypyrimidine tract binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53551/gene-fusions/?id=53551