ZNRF3 (zinc and ring finger 3)

2014-05-01  

Identity

HGNC
ZNRF3
LOCATION
22q12.1
LOCUSID
84133
ALIAS
BK747E2.3,RNF203
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84133
MIM: 612062
HGNC: 18126
Ensembl: ENSG00000183579

Variants:

dbSNP: 84133
ClinVar: 84133
TCGA: ENSG00000183579
COSMIC: ZNRF3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183579ENST00000402174Q9ULT6
ENSG00000183579ENST00000406323Q9ULT6
ENSG00000183579ENST00000544604Q9ULT6
ENSG00000183579ENST00000544604A0A024R1J1

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Regulation of FZD by ubiquitinationREACTOMER-HSA-4641263

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
378789592024Single-Exon Deletions of ZNRF3 Exon 2 Cause Congenital Adrenal Hypoplasia.0
380564652024Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth.1
384572752024Comprehensive analysis of zinc and ring finger 3 in prognostic value and pan-cancer immunity.0
378789592024Single-Exon Deletions of ZNRF3 Exon 2 Cause Congenital Adrenal Hypoplasia.0
380564652024Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth.1
384572752024Comprehensive analysis of zinc and ring finger 3 in prognostic value and pan-cancer immunity.0
366318132023Additional evidence for the role of chromosomal imbalances and SOX8, ZNRF3 and HHAT gene variants in early human testis development.2
366318132023Additional evidence for the role of chromosomal imbalances and SOX8, ZNRF3 and HHAT gene variants in early human testis development.2
350395052022RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.12
350395052022RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.12
333679312021MicroRNA‑301a/ZNRF3/wnt/β‑catenin signal regulatory crosstalk mediates glioma progression.5
335139052021Low Protein Expression of both ATRX and ZNRF3 as Novel Negative Prognostic Markers of Adult Adrenocortical Carcinoma.7
342733742021RSPO2 silence inhibits tumorigenesis of nasopharyngeal carcinoma by ZNRF3/Hedgehog-Gli1 signal pathway.3
345905842021A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling.3
346571412021A positive feedback loop of lncRNA-RMRP/ZNRF3 axis and Wnt/β-catenin signaling regulates the progression and temozolomide resistance in glioma.17

Citation

Dessen P

ZNRF3 (zinc and ring finger 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-05-01

Online version: http://atlasgeneticsoncology.org/gene/53896/favicon/css/lib/js/humanGenome