CTNNA2 (catenin alpha 2)

2014-05-01  

Identity

HGNC
CTNNA2
LOCATION
2p12
LOCUSID
1496
ALIAS
CAP-R,CAPR,CDCBM9,CT114,CTNR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1496
MIM: 114025
HGNC: 2510
Ensembl: ENSG00000066032

Variants:

dbSNP: 1496
ClinVar: 1496
TCGA: ENSG00000066032
COSMIC: CTNNA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000066032ENST00000343114P26232
ENSG00000066032ENST00000361291A0A0A0MRI5
ENSG00000066032ENST00000402739P26232
ENSG00000066032ENST00000409266B8ZZE7
ENSG00000066032ENST00000409550B9A010
ENSG00000066032ENST00000409971C9IZ88
ENSG00000066032ENST00000451966C9J144
ENSG00000066032ENST00000466387P26232
ENSG00000066032ENST00000496558P26232
ENSG00000066032ENST00000540488A0A0A0MTJ6
ENSG00000066032ENST00000541047P26232
ENSG00000066032ENST00000541047F6KRI5
ENSG00000066032ENST00000629316P26232

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Adherens junctionKEGGko04520
Leukocyte transendothelial migrationKEGGko04670
Endometrial cancerKEGGko05213
Adherens junctionKEGGhsa04520
Leukocyte transendothelial migrationKEGGhsa04670
Pathways in cancerKEGGhsa05200
Endometrial cancerKEGGhsa05213
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Bacterial invasion of epithelial cellsKEGGko05100
Bacterial invasion of epithelial cellsKEGGhsa05100
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Developmental BiologyREACTOMER-HSA-1266738
MyogenesisREACTOMER-HSA-525793
CDO in myogenesisREACTOMER-HSA-375170

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalClinicalAnnotation, VariantAnnotationassociatedPD27670765
PA445451PsoriasisDiseaseClinicalAnnotation, VariantAnnotationassociatedPD27670765

References

Pubmed IDYearTitleCitations
305260042019Novel-miR-4885 Promotes Migration and Invasion of Esophageal Cancer Cells Through Targeting CTNNA2.5
305260042019Novel-miR-4885 Promotes Migration and Invasion of Esophageal Cancer Cells Through Targeting CTNNA2.5
287467152017Identification of Genetic Loci Jointly Influencing Schizophrenia Risk and the Cognitive Traits of Verbal-Numerical Reasoning, Reaction Time, and General Cognitive Function.65
287467152017Identification of Genetic Loci Jointly Influencing Schizophrenia Risk and the Cognitive Traits of Verbal-Numerical Reasoning, Reaction Time, and General Cognitive Function.65
271671632016Single nucleotide polymorphisms in the REG-CTNNA2 region of chromosome 2 and NEIL3 associated with impulsivity in a Native American sample.7
274970702016Association of genetic polymorphisms with survival of pancreatic ductal adenocarcinoma patients.8
271671632016Single nucleotide polymorphisms in the REG-CTNNA2 region of chromosome 2 and NEIL3 associated with impulsivity in a Native American sample.7
274970702016Association of genetic polymorphisms with survival of pancreatic ductal adenocarcinoma patients.8
258247432015A pilot genome-wide association study of breast cancer susceptibility loci in Indonesia.10
258247432015A pilot genome-wide association study of breast cancer susceptibility loci in Indonesia.10
250419032014TARV: tree-based analysis of rare variants identifying risk modifying variants in CTNNA2 and CNTNAP2 for alcohol addiction.11
250419032014TARV: tree-based analysis of rare variants identifying risk modifying variants in CTNNA2 and CNTNAP2 for alcohol addiction.11
241006902013Cell-cell adhesion genes CTNNA2 and CTNNA3 are tumour suppressors frequently mutated in laryngeal carcinomas.41
241006902013Cell-cell adhesion genes CTNNA2 and CTNNA3 are tumour suppressors frequently mutated in laryngeal carcinomas.41
228331952011Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking.30

Citation

Dessen P

CTNNA2 (catenin alpha 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-05-01

Online version: http://atlasgeneticsoncology.org/gene/53898/cancer-prone-explorer/deep-insight-explorer/