PHRF1 (PHD and ring finger domains 1)

2014-06-01  

Identity

HGNC
PHRF1
LOCATION
11p15.5
LOCUSID
57661
ALIAS
PPP1R125,RNF221
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57661
MIM: 611780
HGNC: 24351
Ensembl: ENSG00000070047

Variants:

dbSNP: 57661
ClinVar: 57661
TCGA: ENSG00000070047
COSMIC: PHRF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070047ENST00000264555Q9P1Y6
ENSG00000070047ENST00000264555A0A024RCA1
ENSG00000070047ENST00000413872F8WEF5
ENSG00000070047ENST00000416188Q9P1Y6
ENSG00000070047ENST00000533464E9PJ24
ENSG00000070047ENST00000534320Q9P1Y6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
380301672023PHRF1 Promotes Cell Invasion by Modulating SOX4 Expression in Colorectal Cancer HCT116-p53(-/-) Cells.0
380301672023PHRF1 Promotes Cell Invasion by Modulating SOX4 Expression in Colorectal Cancer HCT116-p53(-/-) Cells.0
323602462020Downregulation of a putative tumor suppressor gene PHRF1 in gastric and colorectal cancers.0
323602462020Downregulation of a putative tumor suppressor gene PHRF1 in gastric and colorectal cancers.0
276088402016Overexpression of PHRF1 attenuates the proliferation and tumorigenicity of non-small cell lung cancer cells.4
276088402016Overexpression of PHRF1 attenuates the proliferation and tumorigenicity of non-small cell lung cancer cells.4
258559642015PHRF1 promotes genome integrity by modulating non-homologous end-joining.21
258559642015PHRF1 promotes genome integrity by modulating non-homologous end-joining.21
239112862013Identification of PHRF1 as a tumor suppressor that promotes the TGF-β cytostatic program through selective release of TGIF-driven PML inactivation.20
239112862013Identification of PHRF1 as a tumor suppressor that promotes the TGF-β cytostatic program through selective release of TGIF-driven PML inactivation.20
224339142012Association of PHRF1-IRF7 region polymorphism with clinical manifestations of systemic lupus erythematosus in a Japanese population.10
224339142012Association of PHRF1-IRF7 region polymorphism with clinical manifestations of systemic lupus erythematosus in a Japanese population.10
208810112011Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients.65
209628502011A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles.25
210680982011Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus.69

Citation

Dessen P

PHRF1 (PHD and ring finger domains 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53938/meetings/gene-fusions-explorer/