NAPRT (nicotinate phosphoribosyltransferase)

2014-06-01  

Identity

HGNC
LOCATION
8q24.3
LOCUSID
ALIAS
NAPRT1,PP3856
FUSION GENES

Other Information

Locus ID:

NCBI: 93100
MIM: 611552
HGNC: 30450
Ensembl: ENSG00000147813

Variants:

dbSNP: 93100
ClinVar: 93100
TCGA: ENSG00000147813
COSMIC: NAPRT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147813ENST00000340490G5E977
ENSG00000147813ENST00000426292Q6XQN6
ENSG00000147813ENST00000435154C9J8U2
ENSG00000147813ENST00000449291Q6XQN6
ENSG00000147813ENST00000460623A0A087WUT5
ENSG00000147813ENST00000525583H0YF31
ENSG00000147813ENST00000532645H0YDA6

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Nicotinate and nicotinamide metabolismKEGGko00760
Nicotinate and nicotinamide metabolismKEGGhsa00760
Metabolic pathwaysKEGGhsa01100
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Nicotinate metabolismREACTOMER-HSA-196807
Nicotinamide salvagingREACTOMER-HSA-197264
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
364326022022NAPRT, but Not NAMPT, Provides Additional Support for NAD Synthesis in Esophageal Precancerous Lesions.2
364326022022NAPRT, but Not NAMPT, Provides Additional Support for NAD Synthesis in Esophageal Precancerous Lesions.2
349469712021NAPRT Expression Regulation Mechanisms: Novel Functions Predicted by a Bioinformatics Approach.4
349469712021NAPRT Expression Regulation Mechanisms: Novel Functions Predicted by a Bioinformatics Approach.4
312685072019Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study.25
314398672019PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma.41
315115222019Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation.38
312685072019Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study.25
314398672019PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma.41
315115222019Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation.38
284162762017Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases.9
288601212017NAD Synthesis Pathway Interference Is a Viable Therapeutic Strategy for Chondrosarcoma.27
284162762017Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases.9
288601212017NAD Synthesis Pathway Interference Is a Viable Therapeutic Strategy for Chondrosarcoma.27
266753782016Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors.36

Citation

Dessen P

NAPRT (nicotinate phosphoribosyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/54027/css/gene-fusions/?id=54027