ABCG1 (ATP binding cassette subfamily G member 1)

2014-08-01  

Identity

HGNC
ABCG1
LOCATION
21q22.3
LOCUSID
9619
ALIAS
ABC8,WHITE1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9619
MIM: 603076
HGNC: 73
Ensembl: ENSG00000160179

Variants:

dbSNP: 9619
ClinVar: 9619
TCGA: ENSG00000160179
COSMIC: ABCG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160179ENST00000343687P45844
ENSG00000160179ENST00000347800P45844
ENSG00000160179ENST00000361802P45844
ENSG00000160179ENST00000398437E9PGV9
ENSG00000160179ENST00000398449P45844
ENSG00000160179ENST00000398457P45844
ENSG00000160179ENST00000450121C9JKD9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ABC transportersKEGGko02010
ABC transportersKEGGhsa02010
Transmembrane transport of small moleculesREACTOMER-HSA-382551
ABC-family proteins mediated transportREACTOMER-HSA-382556
ABC transporters in lipid homeostasisREACTOMER-HSA-1369062
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
HDL-mediated lipid transportREACTOMER-HSA-194223

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD26352872
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotationassociatedPD26352872
PA450085irinotecanChemicalClinicalAnnotationassociatedPD26352872
PA450198leucovorinChemicalClinicalAnnotationassociatedPD26352872

References

Pubmed IDYearTitleCitations
378752092024A new perspective on the current and future development potential of ABCG1.1
382752172024The role of ATP-binding cassette transporter G1 (ABCG1) in Alzheimer's disease: A review of the mechanisms.1
378752092024A new perspective on the current and future development potential of ABCG1.1
382752172024The role of ATP-binding cassette transporter G1 (ABCG1) in Alzheimer's disease: A review of the mechanisms.1
360178622023ABCG1 is Expressed in an LXR-Independent Manner in Patients with Type 2 Diabetes Mellitus.0
375077252023Hypomethylation of ABCG1 in peripheral blood as a potential marker for the detection of coronary heart disease.0
377700562023DNA Methylation at ABCG1 and Long-term Changes in Adiposity and Fat Distribution in Response to Dietary Interventions: The POUNDS Lost Trial.1
360178622023ABCG1 is Expressed in an LXR-Independent Manner in Patients with Type 2 Diabetes Mellitus.0
375077252023Hypomethylation of ABCG1 in peripheral blood as a potential marker for the detection of coronary heart disease.0
377700562023DNA Methylation at ABCG1 and Long-term Changes in Adiposity and Fat Distribution in Response to Dietary Interventions: The POUNDS Lost Trial.1
351244252022Expression of ABC transporters during syncytialization in preeclampsia.0
352198122022Genetic variations in ABCA1/G1 associated with plasma lipid levels and risk of ischemic stroke.4
357783162022High nuclear ABCG1 expression is a poor predictor for hepatocellular carcinoma patient survival.4
360650162022Multi-omics analysis identifies rare variation in leptin/PPAR gene sets and hypermethylation of ABCG1 contribute to antipsychotics-induced metabolic syndromes.0
351244252022Expression of ABC transporters during syncytialization in preeclampsia.0

Citation

Dessen P

ABCG1 (ATP binding cassette subfamily G member 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54096/gene-explorer/case-report-explorer/