ABCC5 (ATP binding cassette subfamily C member 5)

2003-06-01  

Identity

HGNC
ABCC5
LOCATION
3q27.1
LOCUSID
10057
ALIAS
ABC33,EST277145,MOAT-C,MOATC,MRP5,SMRP,pABC11
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10057
MIM: 605251
HGNC: 56
Ensembl: ENSG00000114770

Variants:

dbSNP: 10057
ClinVar: 10057
TCGA: ENSG00000114770
COSMIC: ABCC5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114770ENST00000265586O15440
ENSG00000114770ENST00000334444O15440
ENSG00000114770ENST00000382494O15440
ENSG00000114770ENST00000392579O15440
ENSG00000114770ENST00000427120A5PKY6
ENSG00000114770ENST00000437205F8WCY8
ENSG00000114770ENST00000437341C9JZL5
ENSG00000114770ENST00000438979F8WDH3
ENSG00000114770ENST00000443376O15440
ENSG00000114770ENST00000443497H7C271
ENSG00000114770ENST00000446941E9PET4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ABC transportersKEGGko02010
ABC transportersKEGGhsa02010
Transmembrane transport of small moleculesREACTOMER-HSA-382551
ABC-family proteins mediated transportREACTOMER-HSA-382556
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Hyaluronan metabolismREACTOMER-HSA-2142845
Hyaluronan biosynthesis and exportREACTOMER-HSA-2142850
Antifolate resistanceKEGGko01523
Antifolate resistanceKEGGhsa01523

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD26352872
PA131285527oxaliplatinChemicalLiterature, MultilinkAnnotationassociated24924344
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotationassociatedPD26352872
PA449782glibenclamideChemicalVariantAnnotationassociatedPD27403931
PA450085irinotecanChemicalClinicalAnnotationassociatedPD26352872
PA450198leucovorinChemicalClinicalAnnotationassociatedPD26352872
PA451954zidovudineChemicalPathwayassociated22960662

References

Pubmed IDYearTitleCitations
388444522024Inhibition and transport mechanisms of the ABC transporter hMRP5.0
388444522024Inhibition and transport mechanisms of the ABC transporter hMRP5.0
351413322022FOXM1 Promotes Drug Resistance in Cervical Cancer Cells by Regulating ABCC5 Gene Transcription.2
351413322022FOXM1 Promotes Drug Resistance in Cervical Cancer Cells by Regulating ABCC5 Gene Transcription.2
329061292021Association of Single-Nucleotide Polymorphisms in ABCC5 Gene with Primary Angle Closure Glaucoma and the Ocular Biometric Parameters in a Northern Chinese Population.3
342710232021Inhibition of ABCC5-mediated cGMP transport by progesterone, testosterone and their analogues.0
344945102021Pan-cancer analysis and single-cell analysis revealed the role of ABCC5 transporter in hepatocellular carcinoma.7
347681092021ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma.54
329061292021Association of Single-Nucleotide Polymorphisms in ABCC5 Gene with Primary Angle Closure Glaucoma and the Ocular Biometric Parameters in a Northern Chinese Population.3
342710232021Inhibition of ABCC5-mediated cGMP transport by progesterone, testosterone and their analogues.0
344945102021Pan-cancer analysis and single-cell analysis revealed the role of ABCC5 transporter in hepatocellular carcinoma.7
347681092021ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma.54
328287582020MRP5 nitration by NO-releasing gemcitabine encapsulated in liposomes confers sensitivity in chemoresistant pancreatic adenocarcinoma cells.7
328287582020MRP5 nitration by NO-releasing gemcitabine encapsulated in liposomes confers sensitivity in chemoresistant pancreatic adenocarcinoma cells.7
269752272017Pharmacogenetics of ABCB5, ABCC5 and RLIP76 and doxorubicin pharmacokinetics in Asian breast cancer patients.11

Citation

Dessen P

ABCC5 (ATP binding cassette subfamily C member 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/542/favicon/gene-fusions/cancer-prone-explorer/