DGKD (diacylglycerol kinase delta)

2014-08-01  

Identity

HGNC
DGKD
LOCATION
2q37.1
LOCUSID
8527
ALIAS
DGK-delta,DGKdelta,dgkd-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8527
MIM: 601826
HGNC: 2851
Ensembl: ENSG00000077044

Variants:

dbSNP: 8527
ClinVar: 8527
TCGA: ENSG00000077044
COSMIC: DGKD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077044ENST00000264057Q16760
ENSG00000077044ENST00000409813Q16760
ENSG00000077044ENST00000409813A0A024R495
ENSG00000077044ENST00000427930C9JY42
ENSG00000077044ENST00000430834H7BZR7
ENSG00000077044ENST00000442524A0A096LNI6
ENSG00000077044ENST00000447484H7C0L1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Glycerophospholipid metabolismKEGGko00564
Phosphatidylinositol signaling systemKEGGko04070
Glycerolipid metabolismKEGGhsa00561
Glycerophospholipid metabolismKEGGhsa00564
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Effects of PIP2 hydrolysisREACTOMER-HSA-114508
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
319804612020Diacylglycerol kinase δ and sphingomyelin synthase-related protein functionally interact via their sterile α motif domains.10
319804612020Diacylglycerol kinase δ and sphingomyelin synthase-related protein functionally interact via their sterile α motif domains.10
281990872017Expression, Purification, and Properties of a Human Arachidonoyl-Specific Isoform of Diacylglycerol Kinase.6
281990872017Expression, Purification, and Properties of a Human Arachidonoyl-Specific Isoform of Diacylglycerol Kinase.6
231849572013Diacylglycerol kinase δ modulates Akt phosphorylation through pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2).7
231849572013Diacylglycerol kinase δ modulates Akt phosphorylation through pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2).7
224067872012Analysis of the genotype of diacylglycerol kinase delta single-nucleotide polymorphisms in Parkinson disease in the Han Chinese population.0
224067872012Analysis of the genotype of diacylglycerol kinase delta single-nucleotide polymorphisms in Parkinson disease in the Han Chinese population.0
200649312010Diacylglycerol kinase delta and protein kinase C(alpha) modulate epidermal growth factor receptor abundance and degradation through ubiquitin-specific protease 8.16
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
208579262010Zinc binding drives sheet formation by the SAM domain of diacylglycerol kinase δ.13
200649312010Diacylglycerol kinase delta and protein kinase C(alpha) modulate epidermal growth factor receptor abundance and degradation through ubiquitin-specific protease 8.16
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
208579262010Zinc binding drives sheet formation by the SAM domain of diacylglycerol kinase δ.13
182670702008Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.101

Citation

Dessen P

DGKD (diacylglycerol kinase delta)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54253/gene-fusions/tumors-explorer/img/case-report-explorer/