ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group))

2003-02-01  

Identity

HGNC
ABCG2
LOCATION
4q22.1
LOCUSID
9429
ALIAS
ABC15,ABCP,BCRP,BCRP1,BMDP,CD338,CDw338,EST157481,GOUT1,MRX,MXR,MXR-1,MXR1,UAQTL1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9429
MIM: 603756
HGNC: 74
Ensembl: ENSG00000118777

Variants:

dbSNP: 9429
ClinVar: 9429
TCGA: ENSG00000118777
COSMIC: ABCG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118777ENST00000237612Q9UNQ0
ENSG00000118777ENST00000237612A0A024RDD4
ENSG00000118777ENST00000503830F8S0F2
ENSG00000118777ENST00000505480F8S0F2
ENSG00000118777ENST00000515655Q9UNQ0
ENSG00000118777ENST00000650821Q9UNQ0
ENSG00000118777ENST00000650821A0A024RDD4

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ABC transportersKEGGko02010
ABC transportersKEGGhsa02010
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Iron uptake and transportREACTOMER-HSA-917937
MetabolismREACTOMER-HSA-1430728
Abacavir transport and metabolismREACTOMER-HSA-2161522
Abacavir transmembrane transportREACTOMER-HSA-2161517
Antifolate resistanceKEGGko01523
Antifolate resistanceKEGGhsa01523

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10204tenofovirChemicalClinicalAnnotationassociatedPK28462920
PA10804imatinibChemicalClinicalAnnotation, VariantAnnotation, VipGeneassociatedPKPD18981009, 24123600, 24322003, 30713339
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD20530282, 24018773, 24338217
PA130620651anthracyclines and related substancesChemicalVipGeneassociated24021215
PA131285527oxaliplatinChemicalClinicalAnnotationassociatedPD20530282, 24338217
PA131301952gefitinibChemicalClinicalAnnotationassociatedPD17148776, 20035425, 21332310, 25554506
PA133950441hmg coa reductase inhibitorsChemicalLiterature, MultilinkAnnotation, Pathwayassociated25084202
PA134308647rosuvastatinChemicalClinicalAnnotation, DataAnnotation, LabelAnnotation, VipGeneassociatedPKPD19474787, 16784736, 18617601, 19474787, 20130569, 20207952, 20679960, 22331829, 23930675, 25630984, 28322941
PA134865839SLCO1B1GeneDataAnnotationassociated
PA151958383Gastrointestinal Stromal TumorsDiseaseClinicalAnnotationassociatedPD30713339
PA151958596curcuminChemicalVipGeneassociated25587128
PA162372840sunitinibChemicalClinicalAnnotation, VipGeneassociatedPKPD24013576, 25344452, 26244574
PA162372878dasatinibChemicalClinicalAnnotation, VariantAnnotation, VipGeneassociatedPD24322003
PA164712948Opioid anestheticsChemicalClinicalAnnotationassociatedPD30136624
PA164713083Other general anestheticsChemicalClinicalAnnotationassociatedPD30136624
PA164713176Platinum compoundsChemicalPathwayassociated19525887
PA164760843deferasiroxChemicalClinicalAnnotationassociatedPKPD27043265, 27193993, 28346059
PA164924562elacridarChemicalVipGeneassociated
PA165110729rhodamine 123ChemicalVipGeneassociated11559526
PA165110775SN-38ChemicalPathwayassociated
PA165291492pazopanibChemicalMultilinkAnnotationassociated25504632
PA165958345nilotinibChemicalClinicalAnnotation, VariantAnnotation, VipGeneassociatedPD24322003
PA166114961dolutegravirChemicalClinicalAnnotationassociatedPK28858994
PA166131630volatile anestheticsChemicalClinicalAnnotationassociatedPD30136624
PA166154579rs4149056VariantLabelAnnotationassociated
PA166156544rs2231142VariantLabelAnnotationassociated
PA166163418rucaparibChemicalLabelAnnotationassociated
PA166163740apixabanChemicalClinicalAnnotationassociatedPK28678049, 29457840
PA166184498ezetimibe / rosuvastatinChemicalLabelAnnotationassociated
PA378NR1I2GenePathwayassociated21151855
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD20386493, 24394199, 27217051
PA443459Atrial FibrillationDiseaseClinicalAnnotationassociatedPK28678049, 29457840
PA443557Brain NeoplasmsDiseaseClinicalAnnotationassociatedPK27052877
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD18221820
PA443658Central Nervous System InfectionsDiseaseClinicalAnnotationassociatedPK29873816
PA443937Drug ToxicityDiseaseClinicalAnnotationassociatedPD30713339
PA444065EpilepsyDiseaseClinicalAnnotationassociatedPKPD26213157, 27610747, 29791014
PA444101Esophageal NeoplasmsDiseaseVipGeneassociated
PA444318GoutDiseaseClinicalAnnotationassociatedPD26810134, 29341237, 30924126
PA444516HypercholesterolemiaDiseaseClinicalAnnotationassociatedPKPD16784736, 19474787, 20130569, 20207952, 20679960, 23930675, 25630984, 28322941
PA444818Lung NeoplasmsDiseaseClinicalAnnotationassociatedPD17148776, 20035425, 21332310, 25554506
PA445019Myocardial InfarctionDiseaseClinicalAnnotationassociatedPKPD16784736, 19474787, 20130569, 20207952, 20679960, 23930675, 25630984, 28322941
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPKPD24013576, 25344452, 26244574
PA445451PsoriasisDiseaseClinicalAnnotationassociatedPD18256692
PA445601OsteosarcomaDiseaseClinicalAnnotationassociatedPKPD25778468, 29791011
PA445742Stomach NeoplasmsDiseaseVipGeneassociated
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotation, VipGeneassociatedPD20530282, 24018773, 24338217
PA446171Leukemia, Myelogenous, Chronic, BCR-ABL PositiveDiseaseClinicalAnnotationassociatedPD24123600
PA446432beta-ThalassemiaDiseaseClinicalAnnotationassociatedPKPD27043265, 27193993, 28346059
PA447230HIVDiseaseClinicalAnnotationassociatedPKPD23859571, 28462920, 28858994
PA448320allopurinolChemicalClinicalAnnotation, VariantAnnotation, VipGeneassociatedPD26810134, 29341237, 30924126
PA448500atorvastatinChemicalClinicalAnnotation, VipGeneassociatedPKPD19474787
PA448771capecitabineChemicalClinicalAnnotationassociatedPD20530282, 24338217
PA448866ceftriaxoneChemicalClinicalAnnotationassociatedPK29873816
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD
PA449167cyclosporineChemicalVipGeneassociated
PA449212daunorubicinChemicalVipGeneassociated24021215
PA449383docetaxelChemicalPathwayassociated21151855
PA449412doxorubicinChemicalClinicalAnnotation, VipGeneassociatedPD11956086
PA449441efavirenzChemicalClinicalAnnotationassociatedPD23859571
PA449688fluvastatinChemicalClinicalAnnotation, VipGeneassociatedPK19842935
PA449748gemcitabineChemicalClinicalAnnotationassociatedPD
PA450085irinotecanChemicalClinicalAnnotationassociatedPD18221820, 24018773
PA450163lamivudineChemicalPathwayassociated
PA450164lamotrigineChemicalClinicalAnnotationassociatedPKPD26213157, 27610747, 29791014
PA450198leucovorinChemicalClinicalAnnotationassociatedPD20530282, 24018773, 24338217
PA450428methotrexateChemicalClinicalAnnotation, Pathway, VipGeneassociatedPKPD18237272, 18256692, 20386493, 21317831, 25778468, 27217051, 29791011
PA450761paclitaxelChemicalPathwayassociated21151855
PA451089pravastatinChemicalPathway, VipGeneassociated19842935
PA451363simvastatinChemicalClinicalAnnotation, Literature, MultilinkAnnotation, VipGeneassociatedPK19842935, 24598718
PA451547sulfasalazineChemicalClinicalAnnotation, MultilinkAnnotation, VipGeneassociatedPKPD18167504, 24394199, 25872459, 28322941
PA451729topotecanChemicalClinicalAnnotation, VipGeneassociatedPK27052877
PA451954zidovudineChemicalPathwayassociated22960662

References

Pubmed IDYearTitleCitations
377939942024Breast cancer resistance protein polymorphism ABCG2 c.421C>A (rs2231142) moderates the effect of valproate on lamotrigine trough concentrations in adults with epilepsy.0
380120782024Carboranes as Potent Phenyl Mimetics: A Comparative Study on the Reversal of ABCG2-Mediated Drug Resistance by Carboranylquinazolines and Their Organic Isosteres.0
381817892024ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis.2
384099182024NAT10-mediated mRNA N4-acetylcytidine modification of MDR1 and BCRP promotes breast cancer progression.1
384234812024Roles of breast cancer resistance protein and organic anion transporting polypeptide 2B1 in gastrointestinal toxicity induced by SN-38 under inflammatory conditions.0
384266042024Adipocyte‑rich microenvironment promotes chemoresistance via upregulation of peroxisome proliferator‑activated receptor gamma/ABCG2 in epithelial ovarian cancer.1
384421332024ABCG2 transporter reduces protein aggregation in cigarette smoke condensate-exposed A549 lung cancer cells.0
384510122024ABCG2 polymorphisms and susceptibility to ARV-associated hepatotoxicity.1
385420902024ABCG2 Expression as a Potential Survival Predictor in Human Gliomas.0
377939942024Breast cancer resistance protein polymorphism ABCG2 c.421C>A (rs2231142) moderates the effect of valproate on lamotrigine trough concentrations in adults with epilepsy.0
380120782024Carboranes as Potent Phenyl Mimetics: A Comparative Study on the Reversal of ABCG2-Mediated Drug Resistance by Carboranylquinazolines and Their Organic Isosteres.0
381817892024ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis.2
384099182024NAT10-mediated mRNA N4-acetylcytidine modification of MDR1 and BCRP promotes breast cancer progression.1
384234812024Roles of breast cancer resistance protein and organic anion transporting polypeptide 2B1 in gastrointestinal toxicity induced by SN-38 under inflammatory conditions.0
384266042024Adipocyte‑rich microenvironment promotes chemoresistance via upregulation of peroxisome proliferator‑activated receptor gamma/ABCG2 in epithelial ovarian cancer.1

Citation

Dessen P

ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group))

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/546/deep-insight-explorer/css/lib/tumors-explorer/