ABR (ABR activator of RhoGEF and GTPase)

2003-02-01 Affiliation

Identity

HGNC

ABR

LOCATION

17p13.3

LOCUSID

ALIAS

MDB

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 29
MIM: 600365
HGNC: 81
Ensembl: ENSG00000159842

Variants:

dbSNP: 29
ClinVar: 29
TCGA: ENSG00000159842
COSMIC: ABR

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000159842	ENST00000291107	Q12979
ENSG00000159842	ENST00000302538	Q12979
ENSG00000159842	ENST00000536794	B7Z683
ENSG00000159842	ENST00000543210	Q12979
ENSG00000159842	ENST00000544583	Q12979
ENSG00000159842	ENST00000570441	I3L2P5
ENSG00000159842	ENST00000570525	I3L2L3
ENSG00000159842	ENST00000571797	I3NI05
ENSG00000159842	ENST00000571945	I3L1U8
ENSG00000159842	ENST00000572152	I3L379
ENSG00000159842	ENST00000572441	I3L2C0
ENSG00000159842	ENST00000574139	I3L4Y1
ENSG00000159842	ENST00000574266	I3L259
ENSG00000159842	ENST00000574437	A0A1C7CYZ0
ENSG00000159842	ENST00000574544	I3L0R7
ENSG00000159842	ENST00000575770	A0A0D9SGD7
ENSG00000159842	ENST00000575934	I3L3W0

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signalling by NGF	REACTOME	R-HSA-166520
p75 NTR receptor-mediated signalling	REACTOME	R-HSA-193704
Cell death signalling via NRAGE, NRIF and NADE	REACTOME	R-HSA-204998
NRAGE signals death through JNK	REACTOME	R-HSA-193648
Signaling by Rho GTPases	REACTOME	R-HSA-194315
Rho GTPase cycle	REACTOME	R-HSA-194840
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (12/13) signalling events	REACTOME	R-HSA-416482

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
31516309	2019	Genomic/proteomic analyses of dexamethasone-treated human trabecular meshwork cells reveal a role for GULP1 and ABR in phagocytosis.	17
31516309	2019	Genomic/proteomic analyses of dexamethasone-treated human trabecular meshwork cells reveal a role for GULP1 and ABR in phagocytosis.	17
28579391	2017	A RHO Small GTPase Regulator ABR Secures Mitotic Fidelity in Human Embryonic Stem Cells.	5
28579391	2017	A RHO Small GTPase Regulator ABR Secures Mitotic Fidelity in Human Embryonic Stem Cells.	5
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
11921339	2002	Vestibular dysgenesis in mice lacking Abr and Bcr Cdc42/RacGAPs.	17
11921339	2002	Vestibular dysgenesis in mice lacking Abr and Bcr Cdc42/RacGAPs.	17

Citation

Dessen P

ABR (ABR activator of RhoGEF and GTPase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/549/img/deep-insight-explorer/humanGenome