MOB4 (MOB family member 4, phocein)

2014-10-01  

Identity

HGNC
LOCATION
2q33.1
LOCUSID
ALIAS
2C4D,CGI-95,MOB1,MOB3,MOBKL3,PHOCN,PREI3
FUSION GENES

Other Information

Locus ID:

NCBI: 25843
MIM: 609361
HGNC: 17261
Ensembl: ENSG00000115540

Variants:

dbSNP: 25843
ClinVar: 25843
TCGA: ENSG00000115540
COSMIC: MOB4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115540ENST00000233892Q9Y3A3
ENSG00000115540ENST00000323303Q9Y3A3
ENSG00000115540ENST00000323303A0A024R3X9
ENSG00000115540ENST00000409355F8W8B0
ENSG00000115540ENST00000409360Q9Y3A3
ENSG00000115540ENST00000409916B4DM50
ENSG00000115540ENST00000417097F8WAQ8
ENSG00000115540ENST00000448447Q9Y3A3

Expression (GTEx)

0
5
10
15
20
25
30
35

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
372596702023Mob4 is essential for spermatogenesis in Drosophila melanogaster.0
372596702023Mob4 is essential for spermatogenesis in Drosophila melanogaster.0
300723782018The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer.39
300723782018The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer.39
248723892014hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme.12
248723892014hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme.12
183628902008Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1.25
183628902008Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1.25

Citation

Dessen P

MOB4 (MOB family member 4, phocein)

Atlas Genet Cytogenet Oncol Haematol. 2014-10-01

Online version: http://atlasgeneticsoncology.org/gene/54904/js/lib/gene-fusions/?id=54904