P2RY11 (purinergic receptor P2Y11)

2014-10-01  

Identity

HGNC
P2RY11
LOCATION
19p13.2
LOCUSID
5032
ALIAS
P2Y11
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5032
MIM: 602697
HGNC: 8540
Ensembl: ENSG00000244165

Variants:

dbSNP: 5032
ClinVar: 5032
TCGA: ENSG00000244165
COSMIC: P2RY11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000244165ENST00000321826Q96G91

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Nucleotide-like (purinergic) receptorsREACTOMER-HSA-418038
P2Y receptorsREACTOMER-HSA-417957
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384724462024Crosstalk between purinergic receptor P2Y(11) and chemokine receptor CXCR7 is regulated by CXCR4 in human macrophages.0
384724462024Crosstalk between purinergic receptor P2Y(11) and chemokine receptor CXCR7 is regulated by CXCR4 in human macrophages.0
370161722023P2Y(11)/IL-1 receptor crosstalk controls macrophage inflammation: a novel target for anti-inflammatory strategies?2
378811552023Systematic P2Y receptor survey identifies P2Y11 as modulator of immune responses and virus replication in macrophages.2
370161722023P2Y(11)/IL-1 receptor crosstalk controls macrophage inflammation: a novel target for anti-inflammatory strategies?2
378811552023Systematic P2Y receptor survey identifies P2Y11 as modulator of immune responses and virus replication in macrophages.2
361072592022The P2Y(11) receptor of human M2 macrophages activates canonical and IL-1 receptor signaling to translate the extracellular danger signal ATP into anti-inflammatory and pro-angiogenic responses.5
361072592022The P2Y(11) receptor of human M2 macrophages activates canonical and IL-1 receptor signaling to translate the extracellular danger signal ATP into anti-inflammatory and pro-angiogenic responses.5
325318292021Frontline Science: P2Y11 receptors support T cell activation by directing mitochondrial trafficking to the immune synapse.12
337103052021High nocturnal sleep fragmentation is associated with low T lymphocyte P2Y11 protein levels in narcolepsy type 1.1
325318292021Frontline Science: P2Y11 receptors support T cell activation by directing mitochondrial trafficking to the immune synapse.12
337103052021High nocturnal sleep fragmentation is associated with low T lymphocyte P2Y11 protein levels in narcolepsy type 1.1
329942122020The purinergic receptor P2Y11 choreographs the polarization, mitochondrial metabolism, and migration of T lymphocytes.28
329942122020The purinergic receptor P2Y11 choreographs the polarization, mitochondrial metabolism, and migration of T lymphocytes.28
307871052019Lipopolysaccharide suppresses T cells by generating extracellular ATP that impairs their mitochondrial function via P2Y11 receptors.18

Citation

Dessen P

P2RY11 (purinergic receptor P2Y11)

Atlas Genet Cytogenet Oncol Haematol. 2014-10-01

Online version: http://atlasgeneticsoncology.org/gene/54919/tumors-explorer/cancer-prone-explorer/deep-insight-explorer/