NLRP12 (NLR family pyrin domain containing 12)

2015-02-01  

Identity

HGNC
NLRP12
LOCATION
19q13.42
LOCUSID
91662
ALIAS
CLR19.3,FCAS2,NALP12,PAN6,PYPAF7,RNO,RNO2

Other Information

Locus ID:

NCBI: 91662
MIM: 609648
HGNC: 22938
Ensembl: ENSG00000142405

Variants:

dbSNP: 91662
ClinVar: 91662
TCGA: ENSG00000142405
COSMIC: NLRP12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142405ENST00000324134P59046
ENSG00000142405ENST00000345770A0A0C4DH17
ENSG00000142405ENST00000391772A0A0C4DFY3
ENSG00000142405ENST00000391773P59046
ENSG00000142405ENST00000391775P59046

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379762292024NLRP12 Senses the SARS-CoV-2 Membrane Protein and Promotes an Inflammatory Response.1
381772272024The contributions of deleterious rare alleles in NLRP12 and inflammasome-related genes to polymyalgia rheumatica.1
382616572024NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome.3
379762292024NLRP12 Senses the SARS-CoV-2 Membrane Protein and Promotes an Inflammatory Response.1
381772272024The contributions of deleterious rare alleles in NLRP12 and inflammasome-related genes to polymyalgia rheumatica.1
382616572024NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome.3
365991432023High expression of NLRP12 predicts poor prognosis in patients with intracranial glioma.0
375729442023The role of NLRP12 in inflammatory diseases.1
375819372023NLRP12 downregulates the Wnt/β-catenin pathway via interaction with STK38 to suppress colorectal cancer.6
378773652023NLRP12-associated autoinflammatory disease: much more than the FCAS phenotype.0
381234822023NLRP12-associated autoinflammatory disease in Chinese adult patients: a single-centre study.0
365991432023High expression of NLRP12 predicts poor prognosis in patients with intracranial glioma.0
375729442023The role of NLRP12 in inflammatory diseases.1
375819372023NLRP12 downregulates the Wnt/β-catenin pathway via interaction with STK38 to suppress colorectal cancer.6
378773652023NLRP12-associated autoinflammatory disease: much more than the FCAS phenotype.0

Citation

Dessen P

NLRP12 (NLR family pyrin domain containing 12)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/54969/favicon/gene-fusions-explorer/