HOMER1 (homer scaffold protein 1)

2015-02-01  

Identity

HGNC
HOMER1
LOCATION
5q14.1
LOCUSID
9456
ALIAS
HOMER,HOMER1A,HOMER1B,HOMER1C,SYN47,Ves-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9456
MIM: 604798
HGNC: 17512
Ensembl: ENSG00000152413

Variants:

dbSNP: 9456
ClinVar: 9456
TCGA: ENSG00000152413
COSMIC: HOMER1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152413ENST00000282260Q86YM7
ENSG00000152413ENST00000334082Q86YM7
ENSG00000152413ENST00000508576Q86YM7
ENSG00000152413ENST00000535690Q86YM6

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
FoxO signaling pathwayKEGGhsa04068
Neuronal SystemREACTOMER-HSA-112316
Protein-protein interactions at synapsesREACTOMER-HSA-6794362
Interactions of neurexins and neuroligins at synapsesREACTOMER-HSA-6794361

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445254Parkinson DiseaseDiseaseClinicalAnnotationassociatedPD24126708
PA449841haloperidolChemicalMultilinkAnnotationassociated27023437
PA450213levodopaChemicalClinicalAnnotationassociatedPD24126708

References

Pubmed IDYearTitleCitations
361813832022CircHOMER1 aggravates oxidative stress, inflammation and extracellular matrix deposition in high glucose-induced human mesangial cells.1
361813832022CircHOMER1 aggravates oxidative stress, inflammation and extracellular matrix deposition in high glucose-induced human mesangial cells.1
334316622021Multiple signaling pathways are essential for synapse formation induced by synaptic adhesion molecules.20
342044492021The mTORC2 Regulator Homer1 Modulates Protein Levels and Sub-Cellular Localization of the CaSR in Osteoblast-Lineage Cells.4
342255862021The Role of Stress-Induced Changes of Homer1 Expression in Stress Susceptibility.0
347886072021Homer1a regulates Shank3 expression and underlies behavioral vulnerability to stress in a model of Phelan-McDermid syndrome.6
334316622021Multiple signaling pathways are essential for synapse formation induced by synaptic adhesion molecules.20
342044492021The mTORC2 Regulator Homer1 Modulates Protein Levels and Sub-Cellular Localization of the CaSR in Osteoblast-Lineage Cells.4
342255862021The Role of Stress-Induced Changes of Homer1 Expression in Stress Susceptibility.0
347886072021Homer1a regulates Shank3 expression and underlies behavioral vulnerability to stress in a model of Phelan-McDermid syndrome.6
321421002020Self-reported Sleep Problems Related to Amyloid Deposition in Cortical Regions with High HOMER1 Gene Expression.10
326450482020A single nucleotide polymorphism in the HOMER1 gene is associated with sleep latency and theta power in sleep electroencephalogram.2
321421002020Self-reported Sleep Problems Related to Amyloid Deposition in Cortical Regions with High HOMER1 Gene Expression.10
326450482020A single nucleotide polymorphism in the HOMER1 gene is associated with sleep latency and theta power in sleep electroencephalogram.2
310782682019Interaction of the Homer1 EVH1 domain and skeletal muscle ryanodine receptor.5

Citation

Dessen P

HOMER1 (homer scaffold protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/55049/js/lib/tumors-explorer/case-report-explorer/