TARS1 (threonyl-tRNA synthetase 1)

2015-05-01  

Identity

HGNC
TARS1
LOCATION
5p13.3
LOCUSID
6897
ALIAS
TARS,TTD7,ThrRS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6897
MIM: 187790
HGNC: 11572
Ensembl: ENSG00000113407

Variants:

dbSNP: 6897
ClinVar: 6897
TCGA: ENSG00000113407
COSMIC: TARS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113407ENST00000265112P26639
ENSG00000113407ENST00000455217P26639
ENSG00000113407ENST00000502553P26639
ENSG00000113407ENST00000505012D6RCA5
ENSG00000113407ENST00000506040D6RBR8
ENSG00000113407ENST00000507716D6RDJ6
ENSG00000113407ENST00000508361D6RHV7
ENSG00000113407ENST00000509731D6RJ97
ENSG00000113407ENST00000513066D6RCS6
ENSG00000113407ENST00000514259D6R9F8
ENSG00000113407ENST00000626210D6RCS6
ENSG00000113407ENST00000627006D6RHV7

Pathways

PathwaySourceExternal ID
Aminoacyl-tRNA biosynthesisKEGGko00970
Aminoacyl-tRNA biosynthesisKEGGhsa00970
Aminoacyl-tRNA biosynthesis, eukaryotesKEGGhsa_M00359
Aminoacyl-tRNA biosynthesis, eukaryotesKEGGM00359
Gene ExpressionREACTOMER-HSA-74160
tRNA AminoacylationREACTOMER-HSA-379724
Cytosolic tRNA aminoacylationREACTOMER-HSA-379716

References

Pubmed IDYearTitleCitations
389568742024A model organism pipeline provides insight into the clinical heterogeneity of TARS1 loss-of-function variants.0
389568742024A model organism pipeline provides insight into the clinical heterogeneity of TARS1 loss-of-function variants.0
341596252021Contribution of upregulated aminoacyl-tRNA biosynthesis to metabolic dysregulation in gastric cancer.22
341596252021Contribution of upregulated aminoacyl-tRNA biosynthesis to metabolic dysregulation in gastric cancer.22
309029832019A threonyl-tRNA synthetase-mediated translation initiation machinery.36
313742042019Bi-allelic TARS Mutations Are Associated with Brittle Hair Phenotype.28
309029832019A threonyl-tRNA synthetase-mediated translation initiation machinery.36
313742042019Bi-allelic TARS Mutations Are Associated with Brittle Hair Phenotype.28
293280692018Inhibition of MUC1 biosynthesis via threonyl-tRNA synthetase suppresses pancreatic cancer cell migration.17
293280692018Inhibition of MUC1 biosynthesis via threonyl-tRNA synthetase suppresses pancreatic cancer cell migration.17
251638782014Threonyl-tRNA synthetase overexpression correlates with angiogenic markers and progression of human ovarian cancer.17
251638782014Threonyl-tRNA synthetase overexpression correlates with angiogenic markers and progression of human ovarian cancer.17
233756202013Clinical manifestations and outcome of anti-PL7 positive patients with antisynthetase syndrome.21
234259682013Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis.48
233756202013Clinical manifestations and outcome of anti-PL7 positive patients with antisynthetase syndrome.21

Citation

Dessen P

TARS1 (threonyl-tRNA synthetase 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55224/js/hgnc