OSBPL8 (oxysterol binding protein like 8)

2015-06-01  

Identity

HGNC
OSBPL8
LOCATION
12q21.2
LOCUSID
114882
ALIAS
MST120,MSTP120,ORP8,OSBP10
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 114882
MIM: 606736
HGNC: 16396
Ensembl: ENSG00000091039

Variants:

dbSNP: 114882
ClinVar: 114882
TCGA: ENSG00000091039
COSMIC: OSBPL8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000091039ENST00000261183Q9BZF1
ENSG00000091039ENST00000261183A0A024RBB8
ENSG00000091039ENST00000393249Q9BZF1
ENSG00000091039ENST00000393250Q9BZF1
ENSG00000091039ENST00000546946F8VUA7
ENSG00000091039ENST00000547540F8VQX7
ENSG00000091039ENST00000547544F8W060
ENSG00000091039ENST00000548341F8VZ43
ENSG00000091039ENST00000549570F8VVD3
ENSG00000091039ENST00000549646F8VS33
ENSG00000091039ENST00000550628F8W1F1
ENSG00000091039ENST00000551927F8VZB8
ENSG00000091039ENST00000553139F8VVE7
ENSG00000091039ENST00000611266Q9BZF1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Acyl chain remodelling of PSREACTOMER-HSA-1482801

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
323238002020ORP8 induces apoptosis by releasing cytochrome c from mitochondria in non‑small cell lung cancer.6
323238002020ORP8 induces apoptosis by releasing cytochrome c from mitochondria in non‑small cell lung cancer.6
294099002018Both the PH domain and N-terminal region of oxysterol-binding protein related protein 8S are required for localization to PM-ER contact sites.6
294723862018PI(4,5)P(2) controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER-PM contact sites.93
297481342018Oxysterol-binding protein related-proteins (ORPs) 5 and 8 regulate calcium signaling at specific cell compartments.17
294099002018Both the PH domain and N-terminal region of oxysterol-binding protein related protein 8S are required for localization to PM-ER contact sites.6
294723862018PI(4,5)P(2) controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER-PM contact sites.93
297481342018Oxysterol-binding protein related-proteins (ORPs) 5 and 8 regulate calcium signaling at specific cell compartments.17
279839272017Oxysterol-Binding Protein-Related Protein 8 Inhibits Gastric Cancer Growth Through Induction of ER Stress, Inhibition of Wnt Signaling, and Activation of Apoptosis.18
289704842017ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P (2)) and regulate its level at the plasma membrane.85
279839272017Oxysterol-Binding Protein-Related Protein 8 Inhibits Gastric Cancer Growth Through Induction of ER Stress, Inhibition of Wnt Signaling, and Activation of Apoptosis.18
289704842017ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P (2)) and regulate its level at the plasma membrane.85
271137562016ORP5/ORP8 localize to endoplasmic reticulum-mitochondria contacts and are involved in mitochondrial function.122
275301182016Oxysterol binding protein-related protein 8 mediates the cytotoxicity of 25-hydroxycholesterol.14
271137562016ORP5/ORP8 localize to endoplasmic reticulum-mitochondria contacts and are involved in mitochondrial function.122

Citation

Dessen P

OSBPL8 (oxysterol binding protein like 8)

Atlas Genet Cytogenet Oncol Haematol. 2015-06-01

Online version: http://atlasgeneticsoncology.org/gene/55260/css/lib/js/lib/deep-insight-explorer/