EXOC5 (exocyst complex component 5)

2015-06-01  

Identity

HGNC
LOCATION
14q22.3
LOCUSID
ALIAS
HSEC10,PRO1912,SEC10,SEC10L1,SEC10P
FUSION GENES

Other Information

Locus ID:

NCBI: 10640
MIM: 604469
HGNC: 10696
Ensembl: ENSG00000070367

Variants:

dbSNP: 10640
ClinVar: 10640
TCGA: ENSG00000070367
COSMIC: EXOC5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070367ENST00000340918F8W9B8
ENSG00000070367ENST00000413566A0A0A0MSI8
ENSG00000070367ENST00000555148G3V377
ENSG00000070367ENST00000556318G3V4Z7
ENSG00000070367ENST00000621441O00471

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
VxPx cargo-targeting to ciliumREACTOMER-HSA-5620916
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
308245392019The exocyst acting through the primary cilium is necessary for renal ciliogenesis, cystogenesis, and tubulogenesis.14
316949162019Primary cilia and the exocyst are linked to urinary extracellular vesicle production and content.12
308245392019The exocyst acting through the primary cilium is necessary for renal ciliogenesis, cystogenesis, and tubulogenesis.14
316949162019Primary cilia and the exocyst are linked to urinary extracellular vesicle production and content.12
252985252014Exocyst Sec10 protects renal tubule cells from injury by EGFR/MAPK activation and effects on endocytosis.12
252985252014Exocyst Sec10 protects renal tubule cells from injury by EGFR/MAPK activation and effects on endocytosis.12
230379262012Exocyst Sec10 is involved in basolateral protein translation and translocation in the endoplasmic reticulum.2
230379262012Exocyst Sec10 is involved in basolateral protein translation and translocation in the endoplasmic reticulum.2
200537922010Exocyst Sec10 protects epithelial barrier integrity and enhances recovery following oxidative stress, by activation of the MAPK pathway.14
200537922010Exocyst Sec10 protects epithelial barrier integrity and enhances recovery following oxidative stress, by activation of the MAPK pathway.14
192975292009The exocyst protein Sec10 is necessary for primary ciliogenesis and cystogenesis in vitro.112
192975292009The exocyst protein Sec10 is necessary for primary ciliogenesis and cystogenesis in vitro.112
158806022005Association between single-nucleotide polymorphisms in the SEC8L1 gene, which encodes a subunit of the exocyst complex, and rheumatoid arthritis in a Japanese population.6
158806022005Association between single-nucleotide polymorphisms in the SEC8L1 gene, which encodes a subunit of the exocyst complex, and rheumatoid arthritis in a Japanese population.6
146627492003ARF6 controls post-endocytic recycling through its downstream exocyst complex effector.96

Citation

Dessen P

EXOC5 (exocyst complex component 5)

Atlas Genet Cytogenet Oncol Haematol. 2015-06-01

Online version: http://atlasgeneticsoncology.org/gene/55272/js/favicon/deep-insight-explorer/