VDAC3 (voltage dependent anion channel 3)

2015-06-01  

Identity

HGNC
VDAC3
LOCATION
8p11.21
LOCUSID
7419
ALIAS
HD-VDAC3,VDAC-3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7419
MIM: 610029
HGNC: 12674
Ensembl: ENSG00000078668

Variants:

dbSNP: 7419
ClinVar: 7419
TCGA: ENSG00000078668
COSMIC: VDAC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078668ENST00000022615Q9Y277
ENSG00000078668ENST00000518495E5RFL1
ENSG00000078668ENST00000518563E5RK27
ENSG00000078668ENST00000520115E5RHZ6
ENSG00000078668ENST00000521158Q9Y277
ENSG00000078668ENST00000522010E5RHE1
ENSG00000078668ENST00000522069E5RJN6
ENSG00000078668ENST00000522572E5RFP6

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Huntington's diseaseKEGGko05016
Calcium signaling pathwayKEGGhsa04020
Parkinson's diseaseKEGGhsa05012
Huntington's diseaseKEGGhsa05016
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Hepatitis BKEGGhsa05161
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365554962022Specific Post-Translational Modifications of VDAC3 in ALS-SOD1 Model Cells Identified by High-Resolution Mass Spectrometry.1
365554962022Specific Post-Translational Modifications of VDAC3 in ALS-SOD1 Model Cells Identified by High-Resolution Mass Spectrometry.1
317942662020Potentially Critical Roles of NDUFB5, TIMMDC1, and VDAC3 in the Progression of Septic Cardiomyopathy Through Integrated Bioinformatics Analysis.8
319352822020A lower affinity to cytosolic proteins reveals VDAC3 isoform-specific role in mitochondrial biology.28
319743802020Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma.165
320981322020A High Resolution Mass Spectrometry Study Reveals the Potential of Disulfide Formation in Human Mitochondrial Voltage-Dependent Anion Selective Channel Isoforms (hVDACs).13
328296732020Expression of voltage-dependent anion channels in endometrial cancer and its potential prognostic significance.9
317942662020Potentially Critical Roles of NDUFB5, TIMMDC1, and VDAC3 in the Progression of Septic Cardiomyopathy Through Integrated Bioinformatics Analysis.8
319352822020A lower affinity to cytosolic proteins reveals VDAC3 isoform-specific role in mitochondrial biology.28
319743802020Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma.165
320981322020A High Resolution Mass Spectrometry Study Reveals the Potential of Disulfide Formation in Human Mitochondrial Voltage-Dependent Anion Selective Channel Isoforms (hVDACs).13
328296732020Expression of voltage-dependent anion channels in endometrial cancer and its potential prognostic significance.9
284314032017Association of the VDAC3 gene polymorphism with sperm count in Han-Chinese population with idiopathic male infertility.4
289165382017Analysis of blood-based gene expression in idiopathic Parkinson disease.0
284314032017Association of the VDAC3 gene polymorphism with sperm count in Han-Chinese population with idiopathic male infertility.4

Citation

Dessen P

VDAC3 (voltage dependent anion channel 3)

Atlas Genet Cytogenet Oncol Haematol. 2015-06-01

Online version: http://atlasgeneticsoncology.org/gene/55291/js/lib/humanGenome