MYCBP2 (MYC binding protein 2)

2015-08-01  

Identity

HGNC
MYCBP2
LOCATION
13q22.3
LOCUSID
23077
ALIAS
Myc-bp2,PAM,PHR1,Phr
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23077
MIM: 610392
HGNC: 23386
Ensembl: ENSG00000005810

Variants:

dbSNP: 23077
ClinVar: 23077
TCGA: ENSG00000005810
COSMIC: MYCBP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000005810ENST00000357337A0A499FJI4
ENSG00000005810ENST00000429715H7C3U4
ENSG00000005810ENST00000466564A0A087WY34
ENSG00000005810ENST00000544440O75592
ENSG00000005810ENST00000612956A0A0C4DGY7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
382892212024Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function.1
382892212024Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function.1
362003882023Loss-of-function variants in MYCBP2 cause neurobehavioural phenotypes and corpus callosum defects.10
362003882023Loss-of-function variants in MYCBP2 cause neurobehavioural phenotypes and corpus callosum defects.10
365822462022MYCBP2 expression correlated with inflammatory cell infiltration and prognosis immunotherapy in thyroid cancer patients.2
365822462022MYCBP2 expression correlated with inflammatory cell infiltration and prognosis immunotherapy in thyroid cancer patients.2
312855432020FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation.20
312855432020FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation.20
296435112018Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.105
303185072018Epigenetically regulated miR-1247 functions as a novel tumour suppressor via MYCBP2 in methylator colon cancers.10
296435112018Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.105
303185072018Epigenetically regulated miR-1247 functions as a novel tumour suppressor via MYCBP2 in methylator colon cancers.10
254605092015Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors.51
256345362015High myopia-excavated optic disc anomaly associated with a frameshift mutation in the MYC-binding protein 2 gene (MYCBP2).9
257316992015MiR-1247-5p is overexpressed in castration resistant prostate cancer and targets MYCBP2.26

Citation

Dessen P

MYCBP2 (MYC binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55356/case-report-explorer/hgnc