OTUD4 (OTU deubiquitinase 4)

2015-09-01  

Identity

HGNC
OTUD4
LOCATION
4q31.21
LOCUSID
54726
ALIAS
DUBA6,HIN1,HSHIN1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54726
MIM: 611744
HGNC: 24949
Ensembl: ENSG00000164164

Variants:

dbSNP: 54726
ClinVar: 54726
TCGA: ENSG00000164164
COSMIC: OTUD4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164164ENST00000447906Q01804
ENSG00000164164ENST00000454497Q01804
ENSG00000164164ENST00000504501D6RA27
ENSG00000164164ENST00000509620Q01804
ENSG00000164164ENST00000514973D6RI06

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380400502024Deubiquitinating enzyme OTUD4 regulates metastasis in triple-negative breast cancer by stabilizing Snail1.1
384292682024OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway.1
385187212024NRF2 regulates EGF stability through OTUD4 in lung adenocarcinoma.0
380400502024Deubiquitinating enzyme OTUD4 regulates metastasis in triple-negative breast cancer by stabilizing Snail1.1
384292682024OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway.1
385187212024NRF2 regulates EGF stability through OTUD4 in lung adenocarcinoma.0
371498352023Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals OTUD4 in shared dysregulated signatures across pathological subtypes.5
376424062023OTUD4 regulates metastasis and chemoresistance in melanoma by stabilizing Snail1.1
371498352023Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals OTUD4 in shared dysregulated signatures across pathological subtypes.5
376424062023OTUD4 regulates metastasis and chemoresistance in melanoma by stabilizing Snail1.1
329732722020OTUD4 enhances TGFβ signalling through regulation of the TGFβ receptor complex.4
329732722020OTUD4 enhances TGFβ signalling through regulation of the TGFβ receptor complex.4
311386772019New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.12
311386772019New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.12
293950662018OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling.45

Citation

Dessen P

OTUD4 (OTU deubiquitinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2015-09-01

Online version: http://atlasgeneticsoncology.org/gene/55390/gene-explorer/haematological-explorer/gene-explorer/