GPR37 (G protein-coupled receptor 37)

2015-09-01 Affiliation

Identity

HGNC

GPR37

LOCATION

7q31.33

LOCUSID

2861

ALIAS

EDNRBL,PAELR,hET(B)R-LP

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2861
MIM: 602583
HGNC: 4494
Ensembl: ENSG00000170775

Variants:

dbSNP: 2861
ClinVar: 2861
TCGA: ENSG00000170775
COSMIC: GPR37

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000170775	ENST00000303921	O15354

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Parkinson's disease	KEGG	hsa05012
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37732632	2023	Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer.	2
37749229	2023	GPR37 promotes colorectal cancer liver metastases by enhancing the glycolysis and histone lactylation via Hippo pathway.	6
37732632	2023	Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer.	2
37749229	2023	GPR37 promotes colorectal cancer liver metastases by enhancing the glycolysis and histone lactylation via Hippo pathway.	6
35934193	2022	GPR37 promotes cancer growth by binding to CDK6 and represents a new theranostic target in lung adenocarcinoma.	10
35934193	2022	GPR37 promotes cancer growth by binding to CDK6 and represents a new theranostic target in lung adenocarcinoma.	10
33637132	2021	Ecto-GPR37: a potential biomarker for Parkinson's disease.	10
33637132	2021	Ecto-GPR37: a potential biomarker for Parkinson's disease.	10
30423289	2019	GPR37 and GPR37L1 differently interact with dopamine 2 receptors in live cells.	10
30423289	2019	GPR37 and GPR37L1 differently interact with dopamine 2 receptors in live cells.	10
29496607	2018	A novel modelling mechanism of PAEL receptor and GABARAPL2 interaction involved in Parkinson's disease.	6
29973325	2018	[Up-regulation of GPR37 promotes the proliferation of human glioma U251 cells].	3
29496607	2018	A novel modelling mechanism of PAEL receptor and GABARAPL2 interaction involved in Parkinson's disease.	6
29973325	2018	[Up-regulation of GPR37 promotes the proliferation of human glioma U251 cells].	3
27036049	2016	REG4 promotes peritoneal metastasis of gastric cancer through GPR37.	32

Citation

Dessen P

GPR37 (G protein-coupled receptor 37)

Atlas Genet Cytogenet Oncol Haematol. 2015-09-01

Online version: http://atlasgeneticsoncology.org/gene/55392/case-report-explorer/css/haematological-explorer/