CRBN (cereblon)

2016-03-01  

Identity

HGNC
CRBN
LOCATION
3p26.2
LOCUSID
51185
ALIAS
MRT2,MRT2A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51185
MIM: 609262
HGNC: 30185
Ensembl: ENSG00000113851

Variants:

dbSNP: 51185
ClinVar: 51185
TCGA: ENSG00000113851
COSMIC: CRBN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113851ENST00000231948Q96SW2
ENSG00000113851ENST00000231948A0A024R2H8
ENSG00000113851ENST00000424814J3QT87
ENSG00000113851ENST00000432408Q96SW2
ENSG00000113851ENST00000450014J3QT51
ENSG00000113851ENST00000629101A0A0D9SF49
ENSG00000113851ENST00000639284A0A1W2PPJ5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381633192024Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drug-induced thromboembolism.0
381633192024Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drug-induced thromboembolism.0
374586572023Incidence of cereblon protein in intensive care patients: a cross-sectional study.1
374586572023Incidence of cereblon protein in intensive care patients: a cross-sectional study.1
350133002022A proximity biotinylation-based approach to identify protein-E3 ligase interactions induced by PROTACs and molecular glues.15
361649942022CRBN is downregulated in lung cancer and negatively regulates TLR2, 4 and 7 stimulation in lung cancer cells.4
362615292022The E3 ligase adapter cereblon targets the C-terminal cyclic imide degron.21
350133002022A proximity biotinylation-based approach to identify protein-E3 ligase interactions induced by PROTACs and molecular glues.15
361649942022CRBN is downregulated in lung cancer and negatively regulates TLR2, 4 and 7 stimulation in lung cancer cells.4
362615292022The E3 ligase adapter cereblon targets the C-terminal cyclic imide degron.21
334435522021Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple myeloma.63
338303892021Circ_0114428 Regulates Sepsis-Induced Kidney Injury by Targeting the miR-495-3p/CRBN Axis.13
339724002021Cereblon Regulates the Proteotoxicity of Tau by Tuning the Chaperone Activity of DNAJA1.3
341158362021Cereblon enhancer methylation and IMiD resistance in multiple myeloma.21
343735852021Mutations in CRBN and other cereblon pathway genes are infrequently associated with acquired resistance to immunomodulatory drugs.6

Citation

Dessen P

CRBN (cereblon)

Atlas Genet Cytogenet Oncol Haematol. 2016-03-01

Online version: http://atlasgeneticsoncology.org/gene/55691/haematological-explorer/haematological-explorer/gene-explorer/