OTUD3 (OTU deubiquitinase 3)

2016-05-01  

Identity

HGNC
LOCATION
1p36.13
LOCUSID
ALIAS
DUBA4

Other Information

Locus ID:

NCBI: 23252
MIM: 611758
HGNC: 29038
Ensembl: ENSG00000169914

Variants:

dbSNP: 23252
ClinVar: 23252
TCGA: ENSG00000169914
COSMIC: OTUD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169914ENST00000375120Q5T2D3

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ovarian tumor domain proteasesREACTOMER-HSA-5689896

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
361735862022Silencing of LncRNA SNHG6 protects trophoblast cells through regulating miR-101-3p/OTUD3 axis in unexplained recurrent spontaneous abortion.2
365315102022Prevalence and clinical characteristics of T2DM patients with OTUD3 gene rs78466831 SNP at a single academic center in China.1
361735862022Silencing of LncRNA SNHG6 protects trophoblast cells through regulating miR-101-3p/OTUD3 axis in unexplained recurrent spontaneous abortion.2
365315102022Prevalence and clinical characteristics of T2DM patients with OTUD3 gene rs78466831 SNP at a single academic center in China.1
343807802021The deubiquitinase OTUD3 stabilizes ACTN4 to drive growth and metastasis of hepatocellular carcinoma.10
348533152021Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer.14
343807802021The deubiquitinase OTUD3 stabilizes ACTN4 to drive growth and metastasis of hepatocellular carcinoma.10
348533152021Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer.14
324833832020Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer.25
325712542020Tumor suppressor OTUD3 induces growth inhibition and apoptosis by directly deubiquitinating and stabilizing p53 in invasive breast carcinoma cells.13
326790772020Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity.39
327754532020miR-520h Stimulates Drug Resistance to Paclitaxel by Targeting the OTUD3-PTEN Axis in Breast Cancer.12
324833832020Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer.25
325712542020Tumor suppressor OTUD3 induces growth inhibition and apoptosis by directly deubiquitinating and stabilizing p53 in invasive breast carcinoma cells.13
326790772020Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity.39

Citation

Dessen P

OTUD3 (OTU deubiquitinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/55742/css/lib/teaching-explorer/tumors-explorer/