NMUR2 (neuromedin U receptor 2)

2016-06-01 Affiliation

Identity

HGNC

NMUR2

LOCATION

5q33.1

LOCUSID

56923

ALIAS

FM-4,FM4,NMU-R2,NMU2R,TGR-1,TGR1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 56923
MIM: 605108
HGNC: 16454
Ensembl: ENSG00000132911

Variants:

dbSNP: 56923
ClinVar: 56923
TCGA: ENSG00000132911
COSMIC: NMUR2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000132911	ENST00000255262	Q9GZQ4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36543808	2022	A genome-wide association study implicates the pleiotropic effect of NMUR2 on asthma and COPD.	3
36543808	2022	A genome-wide association study implicates the pleiotropic effect of NMUR2 on asthma and COPD.	3
29724789	2018	Ligand-Specific Signaling Profiles and Resensitization Mechanisms of the Neuromedin U2 Receptor.	2
29724789	2018	Ligand-Specific Signaling Profiles and Resensitization Mechanisms of the Neuromedin U2 Receptor.	2
28423716	2017	Oncogenic features of neuromedin U in breast cancer are associated with NMUR2 expression involving crosstalk with members of the WNT signaling pathway.	9
28423716	2017	Oncogenic features of neuromedin U in breast cancer are associated with NMUR2 expression involving crosstalk with members of the WNT signaling pathway.	9
25871004	2015	Polymorphisms in neuropeptide genes and bone mineral density in Korean postmenopausal women.	1
26317338	2015	Identifying a Neuromedin U Receptor 2 Splice Variant and Determining Its Roles in the Regulation of Signaling and Tumorigenesis In Vitro.	8
25871004	2015	Polymorphisms in neuropeptide genes and bone mineral density in Korean postmenopausal women.	1
26317338	2015	Identifying a Neuromedin U Receptor 2 Splice Variant and Determining Its Roles in the Regulation of Signaling and Tumorigenesis In Vitro.	8
16781063	2006	Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones.	4
16781063	2006	Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones.	4

Citation

Dessen P

NMUR2 (neuromedin U receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-06-01

Online version: http://atlasgeneticsoncology.org/gene/55799/cancer-prone-explorer/teaching-explorer/