APBB2 (amyloid beta precursor protein binding family B member 2)

2016-10-01  

Identity

HGNC
APBB2
LOCATION
4p14
LOCUSID
323
ALIAS
FE65L,FE65L1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 323
MIM: 602710
HGNC: 582
Ensembl: ENSG00000163697

Variants:

dbSNP: 323
ClinVar: 323
TCGA: ENSG00000163697
COSMIC: APBB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163697ENST00000295974Q92870
ENSG00000163697ENST00000502841Q92870
ENSG00000163697ENST00000503264D6RDY3
ENSG00000163697ENST00000503503A0A1D5RMR3
ENSG00000163697ENST00000504305Q92870
ENSG00000163697ENST00000506352G5E9Y1
ENSG00000163697ENST00000508593Q92870
ENSG00000163697ENST00000508676D6RAE0
ENSG00000163697ENST00000508707D6RB00
ENSG00000163697ENST00000509446D6RB55
ENSG00000163697ENST00000510670D6RD19
ENSG00000163697ENST00000510925H0Y943
ENSG00000163697ENST00000512510H0YA92
ENSG00000163697ENST00000513140Q92870
ENSG00000163697ENST00000513493H0Y9U9
ENSG00000163697ENST00000513516D6RGD4
ENSG00000163697ENST00000513611H0YAJ5
ENSG00000163697ENST00000514920D6RAJ4
ENSG00000163697ENST00000543538Q92870

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
341651602021miR‑205‑3p promotes lung cancer progression by targeting APBB2.2
341825422021Hsa-miR-30a-3p attenuates gastric adenocarcinoma proliferation and metastasis via APBB2.5
341651602021miR‑205‑3p promotes lung cancer progression by targeting APBB2.2
341825422021Hsa-miR-30a-3p attenuates gastric adenocarcinoma proliferation and metastasis via APBB2.5
316888852019Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.25
316888852019Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.25
293301352018APBB2 is associated with amphetamine use and plasma beta-amyloids in patients receiving methadone maintenance treatment.6
293301352018APBB2 is associated with amphetamine use and plasma beta-amyloids in patients receiving methadone maintenance treatment.6
271573942016Genome-wide expression profiling in the peripheral blood of patients with fibromyalgia.23
271573942016Genome-wide expression profiling in the peripheral blood of patients with fibromyalgia.23
261946142015GSK3β Interactions with Amyloid Genes: An Autopsy Verification and Extension.9
261946142015GSK3β Interactions with Amyloid Genes: An Autopsy Verification and Extension.9
233848212013APBB2 genetic polymorphisms are associated with severe cognitive impairment in centenarians.8
233848212013APBB2 genetic polymorphisms are associated with severe cognitive impairment in centenarians.8
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.19

Citation

Dessen P

APBB2 (amyloid beta precursor protein binding family B member 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/55947/gene-fusions/js/gene-fusions/?id=55947