USP6NL (USP6 N-terminal like)

2016-10-01  

Identity

HGNC
USP6NL
LOCATION
10p14
LOCUSID
9712
ALIAS
RNTRE,TRE2NL,USP6NL-IT1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9712
MIM: 605405
HGNC: 16858
Ensembl: ENSG00000148429

Variants:

dbSNP: 9712
ClinVar: 9712
TCGA: ENSG00000148429
COSMIC: USP6NL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148429ENST00000277575Q92738
ENSG00000148429ENST00000379237X6RAB3
ENSG00000148429ENST00000609104Q92738
ENSG00000148429ENST00000609853V9GYH2

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
330547382020USP6NL mediated by LINC00689/miR-142-3p promotes the development of triple-negative breast cancer.4
330547382020USP6NL mediated by LINC00689/miR-142-3p promotes the development of triple-negative breast cancer.4
296912522018High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis.40
296912522018High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis.40
281835282017Transethnic genome-wide scan identifies novel Alzheimer's disease loci.111
281835282017Transethnic genome-wide scan identifies novel Alzheimer's disease loci.111
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
173718732007Regulation of the Rab5 GTPase-activating protein RN-tre by the dual specificity phosphatase Cdc14A in human cells.15
173718732007Regulation of the Rab5 GTPase-activating protein RN-tre by the dual specificity phosphatase Cdc14A in human cells.15
151522552004Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases.125
151522552004Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases.125

Citation

Dessen P

USP6NL (USP6 N-terminal like)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/55954/deep-insight-explorer/js/welcome