ACSL6 (acyl-CoA synthetase long chain family member 6)

2003-02-01 Affiliation

Identity

HGNC

ACSL6

LOCATION

5q31.1

LOCUSID

23305

ALIAS

ACS2,FACL6,LACS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23305
MIM: 604443
HGNC: 16496
Ensembl: ENSG00000164398

Variants:

dbSNP: 23305
ClinVar: 23305
TCGA: ENSG00000164398
COSMIC: ACSL6

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000164398	ENST00000296869	A0A499FJL5
ENSG00000164398	ENST00000357096	Q9UKU0
ENSG00000164398	ENST00000379240	Q9UKU0
ENSG00000164398	ENST00000379244	Q9UKU0
ENSG00000164398	ENST00000379246	Q9UKU0
ENSG00000164398	ENST00000379255	Q9UKU0
ENSG00000164398	ENST00000414078	C9JPA5
ENSG00000164398	ENST00000416557	C9J4I1
ENSG00000164398	ENST00000419502	C9JK59
ENSG00000164398	ENST00000430403	C9J3Z0
ENSG00000164398	ENST00000431707	E7ERD7
ENSG00000164398	ENST00000434099	C9J8C7
ENSG00000164398	ENST00000441995	C9JT10
ENSG00000164398	ENST00000543479	Q9UKU0
ENSG00000164398	ENST00000650697	A0A494C0B6
ENSG00000164398	ENST00000650912	A0A494C1I9
ENSG00000164398	ENST00000651086	A0A494C0V0
ENSG00000164398	ENST00000651250	A0A494C0J9
ENSG00000164398	ENST00000651269	A0A494C0D5
ENSG00000164398	ENST00000651356	Q9UKU0
ENSG00000164398	ENST00000651427	A0A494BZW8
ENSG00000164398	ENST00000651454	A0A494C046
ENSG00000164398	ENST00000651883	Q9UKU0
ENSG00000164398	ENST00000652424	A0A494C005
ENSG00000164398	ENST00000652493	A0A494C0A5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Fatty acid biosynthesis	KEGG	ko00061
Fatty acid degradation	KEGG	ko00071
PPAR signaling pathway	KEGG	ko03320
Adipocytokine signaling pathway	KEGG	ko04920
Fatty acid biosynthesis	KEGG	hsa00061
Fatty acid degradation	KEGG	hsa00071
PPAR signaling pathway	KEGG	hsa03320
Adipocytokine signaling pathway	KEGG	hsa04920
Peroxisome	KEGG	ko04146
Peroxisome	KEGG	hsa04146
Metabolic pathways	KEGG	hsa01100
beta-Oxidation, acyl-CoA synthesis	KEGG	hsa_M00086
beta-Oxidation, acyl-CoA synthesis	KEGG	M00086
Fatty acid metabolism	KEGG	hsa01212
Fatty acid metabolism	KEGG	ko01212
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolism	REACTOME	R-HSA-535734
Triglyceride Biosynthesis	REACTOME	R-HSA-75109
Fatty Acyl-CoA Biosynthesis	REACTOME	R-HSA-75105
Synthesis of very long-chain fatty acyl-CoAs	REACTOME	R-HSA-75876
Ferroptosis	KEGG	ko04216
Ferroptosis	KEGG	hsa04216

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
34602568	2021	Substrate Specificity of Human Long-Chain Acyl-CoA Synthetase ACSL6 Variants.	1
34602568	2021	Substrate Specificity of Human Long-Chain Acyl-CoA Synthetase ACSL6 Variants.	1
31648559	2019	Acyl-CoA synthetase 6 regulates long-chain polyunsaturated fatty acid composition of membrane phospholipids in spermatids and supports normal spermatogenic processes in mice.	11
31648559	2019	Acyl-CoA synthetase 6 regulates long-chain polyunsaturated fatty acid composition of membrane phospholipids in spermatids and supports normal spermatogenic processes in mice.	11
27647415	2017	Long-chain acyl-CoA synthetase 6 regulates lipid synthesis and mitochondrial oxidative capacity in human and rat skeletal muscle.	27
27647415	2017	Long-chain acyl-CoA synthetase 6 regulates lipid synthesis and mitochondrial oxidative capacity in human and rat skeletal muscle.	27
22205969	2011	ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure.	8
22205969	2011	ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure.	8
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
20429931	2010	Activity of the acyl-CoA synthetase ACSL6 isoforms: role of the fatty acid Gate-domains.	26
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
20429931	2010	Activity of the acyl-CoA synthetase ACSL6 isoforms: role of the fatty acid Gate-domains.	26
18555221	2009	Acyl-CoA synthetase long-chain family member 6 is associated with premature ovarian failure.	3
18555221	2009	Acyl-CoA synthetase long-chain family member 6 is associated with premature ovarian failure.	3
18555221	2009	Acyl-CoA synthetase long-chain family member 6 is associated with premature ovarian failure.	3

Citation

Dessen P

ACSL6 (acyl-CoA synthetase long chain family member 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/560/gene-fusions/css/js/gene-explorer/