IPMK (inositol polyphosphate multikinase)

2016-10-01  

Identity

HGNC
LOCATION
10q21.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 253430
MIM: 609851
HGNC: 20739
Ensembl: ENSG00000151151

Variants:

dbSNP: 253430
ClinVar: 253430
TCGA: ENSG00000151151
COSMIC: IPMK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151151ENST00000373935Q8NFU5

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Pathways

PathwaySourceExternal ID
Inositol phosphate metabolismKEGGko00562
Phosphatidylinositol signaling systemKEGGko04070
Inositol phosphate metabolismKEGGhsa00562
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Inositol phosphate metabolism, Ins(1,3,4)P3 => phytateKEGGM00132
MetabolismREACTOMER-HSA-1430728
Inositol phosphate metabolismREACTOMER-HSA-1483249
Synthesis of IPs in the nucleusREACTOMER-HSA-1855191
Inositol phosphate metabolism, Ins(1,3,4)P3 => phytateKEGGhsa_M00132

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
368307012023miRNA-Induced Downregulation of IPMK in Macrophages Mediates Lipopolysaccharide-Triggered TLR4 Signaling.4
368307012023miRNA-Induced Downregulation of IPMK in Macrophages Mediates Lipopolysaccharide-Triggered TLR4 Signaling.4
334977572021IP6K3 and IPMK variations in LOAD and longevity: Evidence for a multifaceted signaling network at the crossroad between neurodegeneration and survival.7
334977572021IP6K3 and IPMK variations in LOAD and longevity: Evidence for a multifaceted signaling network at the crossroad between neurodegeneration and survival.7
332906952020Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity.29
332906952020Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity.29
307440602019Inositol Polyphosphate Multikinase (IPMK), a Gene Coding for a Potential Moonlighting Protein, Contributes to Human Female Longevity.3
308408912019IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration.22
307440602019Inositol Polyphosphate Multikinase (IPMK), a Gene Coding for a Potential Moonlighting Protein, Contributes to Human Female Longevity.3
308408912019IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration.22
278259212017Familial small-intestine carcinoids: Chromosomal alterations and germline inositol polyphosphate multikinase sequencing.3
288828922017Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities.16
278259212017Familial small-intestine carcinoids: Chromosomal alterations and germline inositol polyphosphate multikinase sequencing.3
288828922017Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities.16
266826492016IPMK: A versatile regulator of nuclear signaling events.20

Citation

Dessen P

IPMK (inositol polyphosphate multikinase)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56057/deep-insight-explorer/css/lib/hgnc