CYP26C1 (cytochrome P450 family 26 subfamily C member 1)

2016-10-01  

Identity

HGNC
CYP26C1
LOCATION
10q23.33
LOCUSID
340665
ALIAS
FFDD4

Other Information

Locus ID:

NCBI: 340665
MIM: 608428
HGNC: 20577
Ensembl: ENSG00000187553

Variants:

dbSNP: 340665
ClinVar: 340665
TCGA: ENSG00000187553
COSMIC: CYP26C1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187553ENST00000624358A0A096LNL5
ENSG00000187553ENST00000651965Q6V0L0

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Retinol metabolismKEGGko00830
Retinol metabolismKEGGhsa00830
Metabolic pathwaysKEGGhsa01100
Signal TransductionREACTOMER-HSA-162582
Signaling by Retinoic AcidREACTOMER-HSA-5362517
RA biosynthesis pathwayREACTOMER-HSA-5365859
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
VitaminsREACTOMER-HSA-211916

References

Pubmed IDYearTitleCitations
346810162021Association of CYP26C1 Promoter Hypomethylation with Small Vessel Occlusion in Korean Subjects.1
346810162021Association of CYP26C1 Promoter Hypomethylation with Small Vessel Occlusion in Korean Subjects.1
314195172019Biochemical and physiological importance of the CYP26 retinoic acid hydroxylases.47
314195172019Biochemical and physiological importance of the CYP26 retinoic acid hydroxylases.47
294760412018CYP26C1 Is a Hydroxylase of Multiple Active Retinoids and Interacts with Cellular Retinoic Acid Binding Proteins.25
297066352018Functional missense and splicing variants in the retinoic acid catabolizing enzyme CYP26C1 in idiopathic short stature.8
294760412018CYP26C1 Is a Hydroxylase of Multiple Active Retinoids and Interacts with Cellular Retinoic Acid Binding Proteins.25
297066352018Functional missense and splicing variants in the retinoic acid catabolizing enzyme CYP26C1 in idiopathic short stature.8
260093092016Elevated expression of the retinoic acid-metabolizing enzyme CYP26C1 in primary breast carcinomas.2
278611282016Retinoic acid catabolizing enzyme CYP26C1 is a genetic modifier in SHOX deficiency.12
260093092016Elevated expression of the retinoic acid-metabolizing enzyme CYP26C1 in primary breast carcinomas.2
278611282016Retinoic acid catabolizing enzyme CYP26C1 is a genetic modifier in SHOX deficiency.12
231616702013Focal facial dermal dysplasia, type IV, is caused by mutations in CYP26C1.19
231616702013Focal facial dermal dysplasia, type IV, is caused by mutations in CYP26C1.19
218501832011Nonsyndromic bilateral and unilateral optic nerve aplasia: first familial occurrence and potential implication of CYP26A1 and CYP26C1 genes.13

Citation

Dessen P

CYP26C1 (cytochrome P450 family 26 subfamily C member 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56075/gene-fusions-explorer/favicon/manifest.json