GRIK5 (glutamate ionotropic receptor kainate type subunit 5)

2016-10-01  

Identity

HGNC
GRIK5
LOCATION
19q13.2
LOCUSID
2901
ALIAS
EAA2,GRIK2,GluK5,KA2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2901
MIM: 600283
HGNC: 4583
Ensembl: ENSG00000105737

Variants:

dbSNP: 2901
ClinVar: 2901
TCGA: ENSG00000105737
COSMIC: GRIK5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105737ENST00000262895Q16478
ENSG00000105737ENST00000301218Q16478
ENSG00000105737ENST00000593562Q16478
ENSG00000105737ENST00000594528M0QXF6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Activation of Kainate Receptors upon glutamate bindingREACTOMER-HSA-451326
Ionotropic activity of Kainate ReceptorsREACTOMER-HSA-451306
Activation of Ca-permeable Kainate ReceptorREACTOMER-HSA-451308

References

Pubmed IDYearTitleCitations
369597462023GRIK5 stimulates colon cancer growth and metastasis through cAMP/PKA/CADM3 signaling.0
369597462023GRIK5 stimulates colon cancer growth and metastasis through cAMP/PKA/CADM3 signaling.0
303398232019A novel function for the ER retention signals in the C-terminus of kainate receptor subunit, GluK5.2
308275002019GRIK5 Genetically Regulated Expression Associated with Eye and Vascular Phenomes: Discovery through Iteration among Biobanks, Electronic Health Records, and Zebrafish.14
303398232019A novel function for the ER retention signals in the C-terminus of kainate receptor subunit, GluK5.2
308275002019GRIK5 Genetically Regulated Expression Associated with Eye and Vascular Phenomes: Discovery through Iteration among Biobanks, Electronic Health Records, and Zebrafish.14
289000782017[Polymorphic Variants of Glutamate Receptor (GRIK5, GRIN2B) and Serotonin Receptor (HTR2A) Genes Are Associated with Chronic Obstructive Pulmonary Disease].1
289000782017[Polymorphic Variants of Glutamate Receptor (GRIK5, GRIN2B) and Serotonin Receptor (HTR2A) Genes Are Associated with Chronic Obstructive Pulmonary Disease].1
232880402013CaMKII-dependent phosphorylation of GluK5 mediates plasticity of kainate receptors.25
232880402013CaMKII-dependent phosphorylation of GluK5 mediates plasticity of kainate receptors.25
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.39
191251032009Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia.4
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.39
191251032009Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia.4
182471292008Human herpesvirus 6 (HHV-6) induces dysregulation of glutamate uptake and transporter expression in astrocytes.15

Citation

Dessen P

GRIK5 (glutamate ionotropic receptor kainate type subunit 5)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56078/gene-fusions-explorer/gene-explorer/tumors-explorer/