KANK2 (KN motif and ankyrin repeat domains 2)

2016-10-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
ANKRD25,MXRA3,NPHS16,PPKWH,SIP
FUSION GENES

Other Information

Locus ID:

NCBI: 25959
MIM: 614610
HGNC: 29300
Ensembl: ENSG00000197256

Variants:

dbSNP: 25959
ClinVar: 25959
TCGA: ENSG00000197256
COSMIC: KANK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197256ENST00000586659Q63ZY3
ENSG00000197256ENST00000588724K7EL48
ENSG00000197256ENST00000588787K7EIU4
ENSG00000197256ENST00000589359Q63ZY3
ENSG00000197256ENST00000589894Q63ZY3
ENSG00000197256ENST00000590685K7ES05
ENSG00000197256ENST00000592675K7ERU2

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
374609772023Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line.1
374609772023Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line.1
342743172021Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A.2
342743172021Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A.2
311140722019A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions.73
311140722019A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions.73
267393302016Association of liprin β-1 with kank proteins in melanoma.7
267393302016Association of liprin β-1 with kank proteins in melanoma.7
259614572015KANK deficiency leads to podocyte dysfunction and nephrotic syndrome.103
259614572015KANK deficiency leads to podocyte dysfunction and nephrotic syndrome.103
246710812014Mutation in KANK2, encoding a sequestering protein for steroid receptor coactivators, causes keratoderma and woolly hair.13
246710812014Mutation in KANK2, encoding a sequestering protein for steroid receptor coactivators, causes keratoderma and woolly hair.13
174763052007SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm.22
174763052007SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm.22

Citation

Dessen P

KANK2 (KN motif and ankyrin repeat domains 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56149/js/teaching-explorer/