ZBTB49 (zinc finger and BTB domain containing 49)

2016-10-01  

Identity

HGNC
ZBTB49
LOCATION
4p16.3
LOCUSID
166793
ALIAS
ZNF509

Other Information

Locus ID:

NCBI: 166793
MIM: 616238
HGNC: 19883
Ensembl: ENSG00000168826

Variants:

dbSNP: 166793
ClinVar: 166793
TCGA: ENSG00000168826
COSMIC: ZBTB49

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168826ENST00000337872Q6ZSB9
ENSG00000168826ENST00000502918D6RJ00
ENSG00000168826ENST00000503703D6RB16
ENSG00000168826ENST00000504302H0Y8P2
ENSG00000168826ENST00000511458H0YAD4
ENSG00000168826ENST00000515012D6RC96

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
287573842017ZNF509S1 downregulates PUMA by inhibiting p53K382 acetylation and p53-DNA binding.1
287573842017ZNF509S1 downregulates PUMA by inhibiting p53K382 acetylation and p53-DNA binding.1
252459462014Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress.8
252459462014Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress.8

Citation

Dessen P

ZBTB49 (zinc finger and BTB domain containing 49)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56245/favicon/css/lib/deep-insight-explorer/