RHOT2 (ras homolog family member T2)

2016-10-01  

Identity

HGNC
RHOT2
LOCATION
16p13.3
LOCUSID
89941
ALIAS
ARHT2,C16orf39,MIRO-2,MIRO2,RASL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 89941
MIM: 613889
HGNC: 21169
Ensembl: ENSG00000140983

Variants:

dbSNP: 89941
ClinVar: 89941
TCGA: ENSG00000140983
COSMIC: RHOT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140983ENST00000315082Q8IXI1
ENSG00000140983ENST00000561929H3BST5
ENSG00000140983ENST00000561983H3BUX4
ENSG00000140983ENST00000562333H3BUX4
ENSG00000140983ENST00000563134I3L2C6
ENSG00000140983ENST00000563637H3BVI5
ENSG00000140983ENST00000566214H3BP40
ENSG00000140983ENST00000569197H3BU27
ENSG00000140983ENST00000570280H3BMP9

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
349921462022MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress Signaling.6
349921462022MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress Signaling.6
329483532021The role of RHOT1 and RHOT2 genetic variation on Parkinson disease risk and onset.0
329483532021The role of RHOT1 and RHOT2 genetic variation on Parkinson disease risk and onset.0
331321892020Insight into human Miro1/2 domain organization based on the structure of its N-terminal GTPase.12
331321892020Insight into human Miro1/2 domain organization based on the structure of its N-terminal GTPase.12
307872022019Epigenetic signature: implications for mitochondrial quality control in human aging.9
307872022019Epigenetic signature: implications for mitochondrial quality control in human aging.9
301115832018Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX.49
304594462018GBF1 and Arf1 interact with Miro and regulate mitochondrial positioning within cells.16
305138252018Human Miro Proteins Act as NTP Hydrolases through a Novel, Non-Canonical Catalytic Mechanism.10
301115832018Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX.49
304594462018GBF1 and Arf1 interact with Miro and regulate mitochondrial positioning within cells.16
305138252018Human Miro Proteins Act as NTP Hydrolases through a Novel, Non-Canonical Catalytic Mechanism.10
276054302016Structural insights into Parkin substrate lysine targeting from minimal Miro substrates.29

Citation

Dessen P

RHOT2 (ras homolog family member T2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56494/css/lib/js/lib/gene-explorer/