NPR3 (natriuretic peptide receptor 3)

2016-10-01  

Identity

HGNC
LOCATION
5p13.3
LOCUSID
ALIAS
ANP-C,ANPR-C,ANPRC,C5orf23,GUCY2B,NPR-C,NPRC
FUSION GENES

Other Information

Locus ID:

NCBI: 4883
MIM: 108962
HGNC: 7945
Ensembl: ENSG00000113389

Variants:

dbSNP: 4883
ClinVar: 4883
TCGA: ENSG00000113389
COSMIC: NPR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113389ENST00000265074P17342
ENSG00000113389ENST00000326958P17342
ENSG00000113389ENST00000415167P17342
ENSG00000113389ENST00000415167Q60I31
ENSG00000113389ENST00000434067C9JK69
ENSG00000113389ENST00000507141H0Y9B9
ENSG00000113389ENST00000509104D6RDL8

Expression (GTEx)

0
5
10
15
20

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
371011782023Genetic evidence implicating natriuretic peptide receptor-3 in cardiovascular disease risk: a Mendelian randomization study.4
375434302023TMT-based quantitative proteomic analysis revealed that FBLN2 and NPR3 are involved in the early osteogenic differentiation of mesenchymal stem cells (MSCs).2
375533742023NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice.3
371011782023Genetic evidence implicating natriuretic peptide receptor-3 in cardiovascular disease risk: a Mendelian randomization study.4
375434302023TMT-based quantitative proteomic analysis revealed that FBLN2 and NPR3 are involved in the early osteogenic differentiation of mesenchymal stem cells (MSCs).2
375533742023NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice.3
346684352022Oxygen and steroids affect the regulatory role of natriuretic peptide receptor-C on surfactant secretion by type II cells.0
346684352022Oxygen and steroids affect the regulatory role of natriuretic peptide receptor-C on surfactant secretion by type II cells.0
342290872021NPR3, transcriptionally regulated by POU2F1, inhibits osteosarcoma cell growth through blocking the PI3K/AKT pathway.9
342290872021NPR3, transcriptionally regulated by POU2F1, inhibits osteosarcoma cell growth through blocking the PI3K/AKT pathway.9
322516052020LncRNA FENDRR Upregulation Promotes Hepatic Carcinoma Cells Apoptosis by Targeting miR-362-5p Via NPR3 and p38-MAPK Pathway.11
322516052020LncRNA FENDRR Upregulation Promotes Hepatic Carcinoma Cells Apoptosis by Targeting miR-362-5p Via NPR3 and p38-MAPK Pathway.11
312345602019Pulmonary Arterial Hypertension Due to NPR-C Mutation: A Novel Paradigm for Normal and Pathologic Remodeling?7
312345602019Pulmonary Arterial Hypertension Due to NPR-C Mutation: A Novel Paradigm for Normal and Pathologic Remodeling?7
290406102018The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle.17

Citation

Dessen P

NPR3 (natriuretic peptide receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56548/favicon/cancer-prone-explorer/