SPC24 (SPC24 component of NDC80 kinetochore complex)

2016-10-01  

Identity

HGNC
SPC24
LOCATION
19p13.2
LOCUSID
147841
ALIAS
SPBC24
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 147841
MIM: 609394
HGNC: 26913
Ensembl: ENSG00000161888

Variants:

dbSNP: 147841
ClinVar: 147841
TCGA: ENSG00000161888
COSMIC: SPC24

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161888ENST00000423327A0A0A0MSN0
ENSG00000161888ENST00000585486K7EJH0
ENSG00000161888ENST00000585567K7ESQ2
ENSG00000161888ENST00000586708K7ERQ7
ENSG00000161888ENST00000591396K7EMX1
ENSG00000161888ENST00000592540Q8NBT2
ENSG00000161888ENST00000592967K7EJV2

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
355438582022LINC02154 promotes the proliferation and metastasis of hepatocellular carcinoma by enhancing SPC24 promoter activity and activating the PI3K-AKT signaling pathway.12
355438582022LINC02154 promotes the proliferation and metastasis of hepatocellular carcinoma by enhancing SPC24 promoter activity and activating the PI3K-AKT signaling pathway.12
340201422021hsa-miR-7-5p suppresses proliferation, migration and promotes apoptosis in hepatocellular carcinoma cell lines by inhibiting SPC24 expression.10
340201422021hsa-miR-7-5p suppresses proliferation, migration and promotes apoptosis in hepatocellular carcinoma cell lines by inhibiting SPC24 expression.10
301809682018SPC24 Regulates breast cancer progression by PI3K/AKT signaling.12
301809682018SPC24 Regulates breast cancer progression by PI3K/AKT signaling.12
284235332017SPC24 is critical for anaplastic thyroid cancer progression.9
284235332017SPC24 is critical for anaplastic thyroid cancer progression.9
265155912015A novel prognostic biomarker SPC24 up-regulated in hepatocellular carcinoma.22
265155912015A novel prognostic biomarker SPC24 up-regulated in hepatocellular carcinoma.22
159614012005Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore.92
159614012005Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore.92
146991292004Identification of two novel components of the human NDC80 kinetochore complex.57
146991292004Identification of two novel components of the human NDC80 kinetochore complex.57

Citation

Dessen P

SPC24 (SPC24 component of NDC80 kinetochore complex)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56627/favicon/favicon/manifest.json