MX2 (MX dynamin like GTPase 2)

2017-04-01  

Identity

HGNC
MX2
LOCATION
21q22.3
LOCUSID
4600
ALIAS
MXB
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4600
MIM: 147890
HGNC: 7533
Ensembl: ENSG00000183486

Variants:

dbSNP: 4600
ClinVar: 4600
TCGA: ENSG00000183486
COSMIC: MX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183486ENST00000330714P20592
ENSG00000183486ENST00000416447C9J9T4
ENSG00000183486ENST00000418103C9JEL4
ENSG00000183486ENST00000435611C9JS04
ENSG00000183486ENST00000436410C9JZQ9

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
367433062023Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients.0
377961302023A single polymorphic residue in humans underlies species-specific restriction of HSV-1 by the antiviral protein MxB.0
367433062023Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients.0
377961302023A single polymorphic residue in humans underlies species-specific restriction of HSV-1 by the antiviral protein MxB.0
355056822022Genetic polymorphisms in the IFNL4, MxA, and MxB genes were associated with biochemical index of chronic HBV patients from Yunnan, China.3
360595472022MX2: Identification and systematic mechanistic analysis of a novel immune-related biomarker for systemic lupus erythematosus.8
355056822022Genetic polymorphisms in the IFNL4, MxA, and MxB genes were associated with biochemical index of chronic HBV patients from Yunnan, China.3
360595472022MX2: Identification and systematic mechanistic analysis of a novel immune-related biomarker for systemic lupus erythematosus.8
337345792021MX2 mediates establishment of interferon response profile, regulates XAF1, and can sensitize melanoma cells to targeted therapy.3
339331702021The transcriptome profile of human trisomy 21 blood cells.11
342823092021MX2-mediated innate immunity against HIV-1 is regulated by serine phosphorylation.13
347071742021High accumulation of Mx2 renders limited multiplication of oncolytic herpes simplex virus-1 in human tumor cells.2
337345792021MX2 mediates establishment of interferon response profile, regulates XAF1, and can sensitize melanoma cells to targeted therapy.3
339331702021The transcriptome profile of human trisomy 21 blood cells.11
342823092021MX2-mediated innate immunity against HIV-1 is regulated by serine phosphorylation.13

Citation

Dessen P

MX2 (MX dynamin like GTPase 2)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56797/tumors-explorer/humanGenome