DLX1 (distal-less homeobox 1)

2017-04-01  

Identity

HGNC
DLX1
LOCATION
2q31.1
LOCUSID
1745
ALIAS
-

Other Information

Locus ID:

NCBI: 1745
MIM: 600029
HGNC: 2914
Ensembl: ENSG00000144355

Variants:

dbSNP: 1745
ClinVar: 1745
TCGA: ENSG00000144355
COSMIC: DLX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144355ENST00000341900P56177
ENSG00000144355ENST00000361609J3KP55
ENSG00000144355ENST00000361725P56177
ENSG00000144355ENST00000361725X5D2F9
ENSG00000144355ENST00000469444F8VXJ2

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383178392024DLX1 acts as a novel prognostic biomarker involved in immune cell infiltration and tumor progression in lung adenocarcinoma.0
383178392024DLX1 acts as a novel prognostic biomarker involved in immune cell infiltration and tumor progression in lung adenocarcinoma.0
326812732021Prospective assessment of two-gene urinary test with multiparametric magnetic resonance imaging of the prostate for men undergoing primary prostate biopsy.18
344721062021MiR-129-5p/DLX1 signalling axis mediates functions of prostate cancer during malignant progression.3
344937332021Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression.15
326812732021Prospective assessment of two-gene urinary test with multiparametric magnetic resonance imaging of the prostate for men undergoing primary prostate biopsy.18
344721062021MiR-129-5p/DLX1 signalling axis mediates functions of prostate cancer during malignant progression.3
344937332021Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression.15
309803912019Long noncoding RNA TUG1 regulates the development of oral squamous cell carcinoma through sponging miR-524-5p to mediate DLX1 expression as a competitive endogenous RNA.22
310262172019Multicenter Optimization and Validation of a 2-Gene mRNA Urine Test for Detection of Clinically Significant Prostate Cancer before Initial Prostate Biopsy.39
309803912019Long noncoding RNA TUG1 regulates the development of oral squamous cell carcinoma through sponging miR-524-5p to mediate DLX1 expression as a competitive endogenous RNA.22
310262172019Multicenter Optimization and Validation of a 2-Gene mRNA Urine Test for Detection of Clinically Significant Prostate Cancer before Initial Prostate Biopsy.39
293172182018DLX1, a binding protein of beta-catenin, promoted the growth and migration of prostate cancer cells.17
300500332018Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1.14
293172182018DLX1, a binding protein of beta-catenin, promoted the growth and migration of prostate cancer cells.17

Citation

Dessen P

DLX1 (distal-less homeobox 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56850/gene-fusions-explorer/tumors-explorer/