COPB2 (COPI coat complex subunit beta 2)

2017-08-01  

Identity

HGNC
COPB2
LOCATION
3q23
LOCUSID
9276
ALIAS
MCPH19,beta-COP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9276
MIM: 606990
HGNC: 2232
Ensembl: ENSG00000184432

Variants:

dbSNP: 9276
ClinVar: 9276
TCGA: ENSG00000184432
COSMIC: COPB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184432ENST00000333188P35606
ENSG00000184432ENST00000503326H0YAC7
ENSG00000184432ENST00000507777P35606
ENSG00000184432ENST00000512153D6RBT6
ENSG00000184432ENST00000512242D6RCL6
ENSG00000184432ENST00000512309H0Y938
ENSG00000184432ENST00000513274D6RBG7
ENSG00000184432ENST00000514508D6RBZ7
ENSG00000184432ENST00000515006D6R997

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
COPI-mediated anterograde transportREACTOMER-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
372966212023β-COP Suppresses the Surface Expression of the TREK2.1
372966212023β-COP Suppresses the Surface Expression of the TREK2.1
357157702022Comprehensive analysis reveals COPB2 and RYK associated with tumor stages of larynx squamous cell carcinoma.2
357157702022Comprehensive analysis reveals COPB2 and RYK associated with tumor stages of larynx squamous cell carcinoma.2
338248742021COPB2: A Novel Prognostic Biomarker That Affects Progression of HCC.5
341011282021COPB2: a transport protein with multifaceted roles in cancer development and progression.10
344500312021COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay.16
346762622021An Integrative Pan-Cancer Analysis of the Oncogenic Role of COPB2 in Human Tumors.3
338248742021COPB2: A Novel Prognostic Biomarker That Affects Progression of HCC.5
341011282021COPB2: a transport protein with multifaceted roles in cancer development and progression.10
344500312021COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay.16
346762622021An Integrative Pan-Cancer Analysis of the Oncogenic Role of COPB2 in Human Tumors.3
316317862020MicroRNA-4461 derived from bone marrow mesenchymal stem cell exosomes inhibits tumorigenesis by downregulating COPB2 expression in colorectal cancer.25
317101832020High expression of COPB2 predicts adverse outcomes: A potential therapeutic target for glioma.14
320042592020Upregulation of the Coatomer Protein Complex Subunit beta 2 (COPB2) Gene Targets microRNA-335-3p in NCI-H1975 Lung Adenocarcinoma Cells to Promote Cell Proliferation and Migration.6

Citation

Dessen P

COPB2 (COPI coat complex subunit beta 2)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57020/favicon/gene-fusions-explorer/deep-insight-explorer/