METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit)

2017-08-01  

Identity

HGNC
METTL3
LOCATION
14q11.2
LOCUSID
56339
ALIAS
IME4,M6A,MT-A70,Spo8,hMETTL3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56339
MIM: 612472
HGNC: 17563
Ensembl: ENSG00000165819

Variants:

dbSNP: 56339
ClinVar: 56339
TCGA: ENSG00000165819
COSMIC: METTL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165819ENST00000298717Q86U44
ENSG00000165819ENST00000377543A0A0G2JH39
ENSG00000165819ENST00000537163B4E349
ENSG00000165819ENST00000539760H0YFV6
ENSG00000165819ENST00000543235B4DTN4
ENSG00000165819ENST00000544248F5H6D8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203

References

Pubmed IDYearTitleCitations
367054302024METTL3 potentiates osteogenic differentiation of bone marrow mesenchymal stem cells via IGF2BP1/m6A/RUNX2.5
372490632024METTL3-mediated ALDH m(6)A methylation regulates the malignant behavior of BMI1(+) HNSCC stem cells.3
376199342024Intracellular Fusobacterium nucleatum infection increases METTL3-mediated m6A methylation to promote the metastasis of esophageal squamous cell carcinoma.6
380136002024METTL3/YTHDF2 m6A axis mediates the progression of diabetic nephropathy through epigenetically suppressing PINK1 and mitophagy.2
380188812024Methyltransferase-like 3-mediated m6A modification of miR-1908-5p contributes to nasopharyngeal carcinoma progression by targeting homeodomain-only protein homeobox.0
380305202024Mettl3-dependent m(6)A modification is essential for effector differentiation and memory formation of CD8(+) T cells.2
380308102024METTL3 facilitates stemness properties and tumorigenicity of cancer stem cells in hepatocellular carcinoma through the SOCS3/JAK2/STAT3 signaling pathway.0
380436282024METTL3 regulates FAM83D m(6)A modification to accelerate tumorigenesis of triple-negative breast cancer via the Wnt/β-catenin pathway.2
381312262024Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review).0
381419062024METTL3 suppresses invasion of lung cancer via SH3BP5 m6A modification.0
381543562024METTL3/YTHDF1 m(6)A axis promotes tumorigenesis by enhancing DDR2 expression in ovarian cancer.2
381667032024The role of the methyltransferase METTL3 in prostate cancer: a potential therapeutic target.2
381901282024FOXM1 Participates in Scleral Remodeling in Myopia by Upregulating APOA1 Expression Through METTL3/YTHDF2.0
382165612024FBXO31 is upregulated by METTL3 to promote pancreatic cancer progression via regulating SIRT2 ubiquitination and degradation.2
382334032024METTL3 facilitates renal cell carcinoma progression by PLOD2 m(6)A-methylation under prolonged hypoxia.0

Citation

Dessen P

METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57050/js/lib/gene-explorer/