WDR4 (WD repeat domain 4)

2017-10-01  

Identity

HGNC
WDR4
LOCATION
21q22.3
LOCUSID
10785
ALIAS
GAMOS6,MIGSB,TRM82,TRMT82,Wuho,hWH
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10785
MIM: 605924
HGNC: 12756
Ensembl: ENSG00000160193

Variants:

dbSNP: 10785
ClinVar: 10785
TCGA: ENSG00000160193
COSMIC: WDR4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160193ENST00000330317P57081
ENSG00000160193ENST00000398208P57081

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
tRNA processingREACTOMER-HSA-72306
tRNA modification in the nucleus and cytosolREACTOMER-HSA-6782315

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
384938822024WDR4 promotes HCC pathogenesis through N(7)-methylguanosine by regulating and interacting with METTL1.1
384938822024WDR4 promotes HCC pathogenesis through N(7)-methylguanosine by regulating and interacting with METTL1.1
365999822023Structures and mechanisms of tRNA methylation by METTL1-WDR4.23
365999852023Structural basis of regulated m(7)G tRNA modification by METTL1-WDR4.20
366816822023Wdr4 promotes cerebellar development and locomotion through Arhgap17-mediated Rac1 activation.1
367334062023Association of RNA m(7)G Modification Gene Polymorphisms with Pediatric Glioma Risk.1
371854582023METTL1/WDR4-mediated tRNA m(7)G modification and mRNA translation control promote oncogenesis and doxorubicin resistance.4
372798512023WDR4/TRIM28 is a novel molecular target linked to lenvatinib resistance that helps retain the stem characteristics in hepatocellular carcinomas.2
378214512023PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target.2
365999822023Structures and mechanisms of tRNA methylation by METTL1-WDR4.23
365999852023Structural basis of regulated m(7)G tRNA modification by METTL1-WDR4.20
366816822023Wdr4 promotes cerebellar development and locomotion through Arhgap17-mediated Rac1 activation.1
367334062023Association of RNA m(7)G Modification Gene Polymorphisms with Pediatric Glioma Risk.1
371854582023METTL1/WDR4-mediated tRNA m(7)G modification and mRNA translation control promote oncogenesis and doxorubicin resistance.4
372798512023WDR4/TRIM28 is a novel molecular target linked to lenvatinib resistance that helps retain the stem characteristics in hepatocellular carcinomas.2

Citation

Dessen P

WDR4 (WD repeat domain 4)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57078/css/case-report-explorer/