TAS2R8 (taste 2 receptor member 8)

2017-10-01 Affiliation

Identity

HGNC

TAS2R8

LOCATION

12p13.2

LOCUSID

50836

ALIAS

T2R8,TRB5

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 50836
MIM: 604794
HGNC: 14915
Ensembl: ENSG00000121314

Variants:

dbSNP: 50836
ClinVar: 50836
TCGA: ENSG00000121314
COSMIC: TAS2R8

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000121314	ENST00000240615	Q9NYW2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Taste transduction	KEGG	ko04742
Taste transduction	KEGG	hsa04742
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)	REACTOME	R-HSA-420499
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594

References

Pubmed ID	Year	Title	Citations
33071257	2020	Intracellular zinc-dependent TAS2R8 gene expression through CTCF activation.	1
33071257	2020	Intracellular zinc-dependent TAS2R8 gene expression through CTCF activation.	1
28467517	2017	Anti-cancer stemness and anti-invasive activity of bitter taste receptors, TAS2R8 and TAS2R10, in human neuroblastoma cells.	18
28467517	2017	Anti-cancer stemness and anti-invasive activity of bitter taste receptors, TAS2R8 and TAS2R10, in human neuroblastoma cells.	18
21670512	2011	Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides.	5
21670512	2011	Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides.	5

Citation

Dessen P

TAS2R8 (taste 2 receptor member 8)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57103/css/humanGenome