NFS1 (NFS1 cysteine desulfurase)

2018-07-01  

Identity

HGNC
NFS1
LOCATION
20q11.22
LOCUSID
9054
ALIAS
HUSSY-08,IscS,NIFS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9054
MIM: 603485
HGNC: 15910
Ensembl: ENSG00000244005

Variants:

dbSNP: 9054
ClinVar: 9054
TCGA: ENSG00000244005
COSMIC: NFS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000244005ENST00000306750Q8WV90
ENSG00000244005ENST00000374085Q9Y697
ENSG00000244005ENST00000374085Q5QP19
ENSG00000244005ENST00000374092Q9Y697
ENSG00000244005ENST00000397425Q9Y697
ENSG00000244005ENST00000397425Q5QP19
ENSG00000244005ENST00000413203F8WER8
ENSG00000244005ENST00000419569A2A2M1
ENSG00000244005ENST00000440385F2Z2E7
ENSG00000244005ENST00000456462F8WB23
ENSG00000244005ENST00000541387Q9Y697

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Thiamine metabolismKEGGko00730
Thiamine metabolismKEGGhsa00730
Metabolic pathwaysKEGGhsa01100
Sulfur relay systemKEGGko04122
Sulfur relay systemKEGGhsa04122
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Molybdenum cofactor biosynthesisREACTOMER-HSA-947581
Mitochondrial iron-sulfur cluster biogenesisREACTOMER-HSA-1362409

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
352213312022Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis.68
352213312022Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis.68
308171342019Analysis of the Cellular Roles of MOCS3 Identifies a MOCS3-Independent Localization of NFS1 at the Tips of the Centrosome.5
311018072019Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism.62
308171342019Analysis of the Cellular Roles of MOCS3 Identifies a MOCS3-Independent Localization of NFS1 at the Tips of the Centrosome.5
311018072019Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism.62
299833742018Architectural Features of Human Mitochondrial Cysteine Desulfurase Complexes from Crosslinking Mass Spectrometry and Small-Angle X-Ray Scattering.9
300318762018Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity.11
299833742018Architectural Features of Human Mitochondrial Cysteine Desulfurase Complexes from Crosslinking Mass Spectrometry and Small-Angle X-Ray Scattering.9
300318762018Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity.11
280010422017Human Mitochondrial Ferredoxin 1 (FDX1) and Ferredoxin 2 (FDX2) Both Bind Cysteine Desulfurase and Donate Electrons for Iron-Sulfur Cluster Biosynthesis.56
282718772017The N-Terminus of Iron-Sulfur Cluster Assembly Factor ISD11 Is Crucial for Subcellular Targeting and Interaction with l-Cysteine Desulfurase NFS1.9
286343022017Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions.79
287663352017Functional Complementation Studies Reveal Different Interaction Partners of Escherichia coli IscS and Human NFS1.5
291685062017NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis.313

Citation

Dessen P

NFS1 (NFS1 cysteine desulfurase)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57449/gene-fusions-explorer/meetings/teaching-explorer/