NUDT5 (nudix hydrolase 5)

2018-07-01  

Identity

HGNC
NUDT5
LOCATION
10p14
LOCUSID
11164
ALIAS
YSA1,YSA1H,YSAH1,hNUDT5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11164
MIM: 609230
HGNC: 8052
Ensembl: ENSG00000165609

Variants:

dbSNP: 11164
ClinVar: 11164
TCGA: ENSG00000165609
COSMIC: NUDT5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165609ENST00000378927A6NCQ0
ENSG00000165609ENST00000378937A6NFX8
ENSG00000165609ENST00000378940A6NJU6
ENSG00000165609ENST00000444732C9JYY9
ENSG00000165609ENST00000476462H0YEY4
ENSG00000165609ENST00000491614Q9UKK9
ENSG00000165609ENST00000537776Q9UKK9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Purine metabolismKEGGhsa00230
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Phosphate bond hydrolysis by NUDT proteinsREACTOMER-HSA-2393930

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383172312024The novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth.1
383172312024The novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth.1
371561972023NUDT5-Determines the fate of head and neck squamous cell carcinoma cells under endoplasmic reticulum stress by catalyzing nuclear ATP production to promote DNA repair.0
371561972023NUDT5-Determines the fate of head and neck squamous cell carcinoma cells under endoplasmic reticulum stress by catalyzing nuclear ATP production to promote DNA repair.0
352473772022Silencing of Nudix type 5 represses proliferation and invasion and enhances chemosensitivity of gastric carcinoma cells by affecting the AKT/GSK-3β/β-catenin pathway.2
352473772022Silencing of Nudix type 5 represses proliferation and invasion and enhances chemosensitivity of gastric carcinoma cells by affecting the AKT/GSK-3β/β-catenin pathway.2
330961442021The high expression of MTH1 and NUDT5 promotes tumor metastasis and indicates a poor prognosis in patients with non-small-cell lung cancer.4
335712432021The high expression of NUDT5 indicates poor prognosis of breast cancer by modulating AKT / Cyclin D signaling.7
330961442021The high expression of MTH1 and NUDT5 promotes tumor metastasis and indicates a poor prognosis in patients with non-small-cell lung cancer.4
335712432021The high expression of NUDT5 indicates poor prognosis of breast cancer by modulating AKT / Cyclin D signaling.7
293438272018Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.25
293438272018Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.25
272572572016ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling.79
272572572016ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling.79
235818892013Lowered Nudix type 5 expression leads to cellular senescence in IMR-90 fibroblast cells.3

Citation

Dessen P

NUDT5 (nudix hydrolase 5)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57484/js/cancer-prone-explorer/