CHAC2 (ChaC glutathione specific gamma-glutamylcyclotransferase 2)

2018-07-01  

Identity

HGNC
CHAC2
LOCATION
2p16.2
LOCUSID
494143
ALIAS
GCG1

Other Information

Locus ID:

NCBI: 494143
MIM: 617446
HGNC: 32363
Ensembl: ENSG00000143942

Variants:

dbSNP: 494143
ClinVar: 494143
TCGA: ENSG00000143942
COSMIC: CHAC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143942ENST00000295304Q8WUX2

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Glutathione synthesis and recyclingREACTOMER-HSA-174403

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381904832024E3 ubiquitin ligase RNF148 functions as an oncogene in colorectal cancer by ubiquitination-mediated degradation of CHAC2.0
381904832024E3 ubiquitin ligase RNF148 functions as an oncogene in colorectal cancer by ubiquitination-mediated degradation of CHAC2.0
318782592019Structural and Functional Analyses of Human ChaC2 in Glutathione Metabolism.8
318782592019Structural and Functional Analyses of Human ChaC2 in Glutathione Metabolism.8
279136232017ChaC2, an Enzyme for Slow Turnover of Cytosolic Glutathione.26
288371562017CHAC2, downregulated in gastric and colorectal cancers, acted as a tumor suppressor inducing apoptosis and autophagy through unfolded protein response.12
290545452017CHAC2 is essential for self-renewal and glutathione maintenance in human embryonic stem cells.16
279136232017ChaC2, an Enzyme for Slow Turnover of Cytosolic Glutathione.26
288371562017CHAC2, downregulated in gastric and colorectal cancers, acted as a tumor suppressor inducing apoptosis and autophagy through unfolded protein response.12
290545452017CHAC2 is essential for self-renewal and glutathione maintenance in human embryonic stem cells.16

Citation

Dessen P

CHAC2 (ChaC glutathione specific gamma-glutamylcyclotransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57487/css/lib/hgnc