IFI35 (interferon induced protein 35)

2018-07-01  

Identity

HGNC
IFI35
LOCATION
17q21.31
LOCUSID
3430
ALIAS
IFP35
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3430
MIM: 600735
HGNC: 5399
Ensembl: ENSG00000068079

Variants:

dbSNP: 3430
ClinVar: 3430
TCGA: ENSG00000068079
COSMIC: IFI35

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000068079ENST00000415816P80217
ENSG00000068079ENST00000438323P80217

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
343628452021IFP35 family proteins promote neuroinflammation and multiple sclerosis.10
343628452021IFP35 family proteins promote neuroinflammation and multiple sclerosis.10
327810672020IFI35 as a biomolecular marker of neuroinflammation and treatment response in multiple sclerosis.6
327810672020IFI35 as a biomolecular marker of neuroinflammation and treatment response in multiple sclerosis.6
293508812018Interferon-induced protein 35 inhibits endothelial cell proliferation, migration and re-endothelialization of injured arteries by inhibiting the nuclear factor-kappa B pathway.20
293508812018Interferon-induced protein 35 inhibits endothelial cell proliferation, migration and re-endothelialization of injured arteries by inhibiting the nuclear factor-kappa B pathway.20
280645412017The role of IFI35 in lupus nephritis and related mechanisms.11
281099792017Interferon (IFN)-induced protein 35 (IFI35) negatively regulates IFN-β-phosphorylated STAT1-RIG-I-CXCL10/CCL5 axis in U373MG astrocytoma cells treated with polyinosinic-polycytidylic acid.14
290384652017NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury.32
280645412017The role of IFI35 in lupus nephritis and related mechanisms.11
281099792017Interferon (IFN)-induced protein 35 (IFI35) negatively regulates IFN-β-phosphorylated STAT1-RIG-I-CXCL10/CCL5 axis in U373MG astrocytoma cells treated with polyinosinic-polycytidylic acid.14
290384652017NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury.32
276396182016Interferon (IFN)-Induced Protein 35 (IFI35), a Type I Interferon-Dependent Transcript, Upregulates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells.8
276396182016Interferon (IFN)-Induced Protein 35 (IFI35), a Type I Interferon-Dependent Transcript, Upregulates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells.8
263424642015Trim21 regulates Nmi-IFI35 complex-mediated inhibition of innate antiviral response.22

Citation

Dessen P

IFI35 (interferon induced protein 35)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57542/css/gene-fusions/deep-insight-explorer/