HKDC1 (hexokinase domain containing 1)

2018-07-01  

Identity

HGNC
LOCATION
10q22.1
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 80201
MIM: 617221
HGNC: 23302
Ensembl: ENSG00000156510

Variants:

dbSNP: 80201
ClinVar: 80201
TCGA: ENSG00000156510
COSMIC: HKDC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156510ENST00000354624Q2TB90

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Fructose and mannose metabolismKEGGko00051
Galactose metabolismKEGGko00052
Starch and sucrose metabolismKEGGko00500
Amino sugar and nucleotide sugar metabolismKEGGko00520
Insulin signaling pathwayKEGGko04910
Type II diabetes mellitusKEGGko04930
Glycolysis / GluconeogenesisKEGGhsa00010
Fructose and mannose metabolismKEGGhsa00051
Galactose metabolismKEGGhsa00052
Starch and sucrose metabolismKEGGhsa00500
Amino sugar and nucleotide sugar metabolismKEGGhsa00520
Insulin signaling pathwayKEGGhsa04910
Type II diabetes mellitusKEGGhsa04930
Metabolic pathwaysKEGGhsa01100
Neomycin, kanamycin and gentamicin biosynthesisKEGGko00524
Neomycin, kanamycin and gentamicin biosynthesisKEGGhsa00524
Carbohydrate digestion and absorptionKEGGko04973
Carbohydrate digestion and absorptionKEGGhsa04973
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGhsa_M00001
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGM00001
Nucleotide sugar biosynthesis, glucose => UDP-glucoseKEGGhsa_M00549
Nucleotide sugar biosynthesis, glucose => UDP-glucoseKEGGM00549
HIF-1 signaling pathwayKEGGhsa04066
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
Central carbon metabolism in cancerKEGGhsa05230
Central carbon metabolism in cancerKEGGko05230

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380096492024CircVMP1 promotes glycolysis and disease progression by upregulating HKDC1 in colorectal cancer.0
383510962024HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression.0
386367682024Hepatitis B virus X protein promotes tumor glycolysis by downregulating lncRNA OIP5-AS1/HKDC1 in HCC.0
380096492024CircVMP1 promotes glycolysis and disease progression by upregulating HKDC1 in colorectal cancer.0
383510962024HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression.0
386367682024Hepatitis B virus X protein promotes tumor glycolysis by downregulating lncRNA OIP5-AS1/HKDC1 in HCC.0
374235582023HKDC1 reprograms lipid metabolism to enhance gastric cancer metastasis and cisplatin resistance via forming a ribonucleoprotein complex.4
379450182023HKDC1 in Gastric Cancer: A New Diagnostic, Prognostic Biomarker, and Novel Therapeutic Target.0
374235582023HKDC1 reprograms lipid metabolism to enhance gastric cancer metastasis and cisplatin resistance via forming a ribonucleoprotein complex.4
379450182023HKDC1 in Gastric Cancer: A New Diagnostic, Prognostic Biomarker, and Novel Therapeutic Target.0
354856482022The HOXC-AS2/miR-876-5p/HKDC1 axis regulates endometrial cancer progression in a high glucose-related tumor microenvironment.8
354856482022The HOXC-AS2/miR-876-5p/HKDC1 axis regulates endometrial cancer progression in a high glucose-related tumor microenvironment.8
333097782021Integrated Multiomics Reveals Glucose Use Reprogramming and Identifies a Novel Hexokinase in Alcoholic Hepatitis.28
342324122021The Role of Hexokinase Domain Containing Protein-1 in Glucose Regulation During Pregnancy.2
333097782021Integrated Multiomics Reveals Glucose Use Reprogramming and Identifies a Novel Hexokinase in Alcoholic Hepatitis.28

Citation

Dessen P

HKDC1 (hexokinase domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57598/js/lib/hgnc