ZC3HAV1 (zinc finger CCCH-type containing, antiviral 1)

2018-12-01  

Identity

HGNC
ZC3HAV1
LOCATION
7q34
LOCUSID
56829
ALIAS
ARTD13,FLB6421,PARP13,ZAP,ZC3H2,ZC3HDC2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56829
MIM: 607312
HGNC: 23721
Ensembl: ENSG00000105939

Variants:

dbSNP: 56829
ClinVar: 56829
TCGA: ENSG00000105939
COSMIC: ZC3HAV1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105939ENST00000242351Q7Z2W4
ENSG00000105939ENST00000460845H7C5K1
ENSG00000105939ENST00000464606C9J6P4
ENSG00000105939ENST00000471652Q7Z2W4

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Oncogenic MAPK signalingREACTOMER-HSA-6802957
Signaling by BRAF and RAF fusionsREACTOMER-HSA-6802952

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
372215582023Association of ZC3HAV1 single nucleotide polymorphisms with the susceptibility of Vogt-Koyanagi-Harada Disease.0
372215582023Association of ZC3HAV1 single nucleotide polymorphisms with the susceptibility of Vogt-Koyanagi-Harada Disease.0
349370412022Expression of Zinc-Finger Antiviral Protein in hCMEC/D3 Human Cerebral Microvascular Endothelial Cells: Effect of a Toll-Like Receptor 3 Agonist.1
351653002022The low abundance of CpG in the SARS-CoV-2 genome is not an evolutionarily signature of ZAP.2
358818052022ZAP isoforms regulate unfolded protein response and epithelial- mesenchymal transition.5
349370412022Expression of Zinc-Finger Antiviral Protein in hCMEC/D3 Human Cerebral Microvascular Endothelial Cells: Effect of a Toll-Like Receptor 3 Agonist.1
351653002022The low abundance of CpG in the SARS-CoV-2 genome is not an evolutionarily signature of ZAP.2
358818052022ZAP isoforms regulate unfolded protein response and epithelial- mesenchymal transition.5
334082332021Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7.10
334750842021Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets.34
338057692021The Interaction of Human and Epstein-Barr Virus miRNAs with Multiple Sclerosis Risk Loci.17
339477662021The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4/UL5 Transcripts.22
343199122021ZC3HAV1 promotes the proliferation and metastasis via regulating KRAS in pancreatic cancer.10
334082332021Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7.10
334750842021Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets.34

Citation

Dessen P

ZC3HAV1 (zinc finger CCCH-type containing, antiviral 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-12-01

Online version: http://atlasgeneticsoncology.org/gene/57769/cancer-prone-explorer/teaching-explorer/