SPSB3 (splA/ryanodine receptor domain and SOCS box containing 3)

2019-04-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
C16orf31,SSB3
FUSION GENES

Other Information

Locus ID:

NCBI: 90864
MIM: 611659
HGNC: 30629
Ensembl: ENSG00000162032

Variants:

dbSNP: 90864
ClinVar: 90864
TCGA: ENSG00000162032
COSMIC: SPSB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162032ENST00000301717Q6PJ21
ENSG00000162032ENST00000566339Q6PJ21
ENSG00000162032ENST00000569769H3BP12

Expression (GTEx)

0
50
100
150
200

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
384188822024The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation.2
384188822024The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation.2
290591702018SPSB3 targets SNAIL for degradation in GSK-3β phosphorylation-dependent manner and regulates metastasis.28
290591702018SPSB3 targets SNAIL for degradation in GSK-3β phosphorylation-dependent manner and regulates metastasis.28
205322022010Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.42
205322022010Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.42

Citation

Dessen P

SPSB3 (splA/ryanodine receptor domain and SOCS box containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57832/favicon/gene-fusions-explorer/